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laminin B1

Summary

Gene Symbol

Lamb1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16777

PubChem

16777

Alliance of Genome Resources

MGI:96743

Annotation

Keyword

3D-structure
Basement membrane
Cell adhesion
Coiled coil
Direct protein sequencing
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E9QN70
Q3UHL7
P02469	Laminin B1 chain Laminin-1 subunit beta Laminin-10 subunit beta Laminin-12 subunit beta Laminin-2 subunit beta Laminin-6 subunit beta Laminin-8 subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
cell adhesion	IEA
negative regulation of cell adhesion	IDA	7639691
axon guidance	IBA
embryo implantation	IMP	15102706
learning or memory	NAS	15207330

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

cell-cell adhesion [inference]

neuronal-glial interaction involved in cerebral cortex radial glia guided migration

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

basement membrane assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

reproductive process [inference]

embryo implantation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

odontogenesis

anatomical structure development [inference]

tissue development

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
basement membrane	ISS
basement membrane	ISO
basement membrane	NAS	1678389
basement membrane	IDA	12631063 12743034 1292752 15102706 15895400 16041630 16631359 18757743 9264260 9396756

GO Hierarchy

cellular component

protein-containing complex [inference]

laminin complex

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
integrin binding	IMP	9004048
integrin binding	IBA
extracellular matrix structural constituent	RCA	22159717 28071719
extracellular matrix structural constituent	ISS
extracellular matrix structural constituent	ISO

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding

cell adhesion molecule binding [inference]

integrin binding

lipid binding [inference]

sphingolipid binding [inference]

glycosphingolipid binding

glycolipid binding [inference]

glycosphingolipid binding

protein-containing complex binding [inference]

integrin binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

glycosphingolipid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Laminin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
animal organ morphogenesis
basement membrane assembly
cell migration
substrate adhesion-dependent cell spreading
tissue development

Displaying **all 2** entries
InterPro
Laminin, N-terminal
Laminin-type EGF domain

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3912	Xenbase:XB-GENE-1011014	HUMAN90785
Caenorhabditis elegans	3913	WB:WBGene00002247
Caenorhabditis elegans	3914	WB:WBGene00002247
Xenopus tropicalis	16777	Xenbase:XB-GENE-1011014
Caenorhabditis elegans	16779	WB:WBGene00002247
Caenorhabditis elegans	22798	WB:WBGene00002247
Caenorhabditis elegans	25473	WB:WBGene00002247
Xenopus tropicalis	177292	Xenbase:XB-GENE-1011014
Danio rerio	286830		DANRE26830
Rattus norvegicus	298941		RATNO35744