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laminin, beta 2

Summary

Gene Symbol

Lamb2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16779

PubChem

16779

Alliance of Genome Resources

MGI:99916

Annotation

Keyword

Basement membrane
Cell adhesion
Coiled coil
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q61292	Laminin-11 subunit beta Laminin-14 subunit beta Laminin-15 subunit beta Laminin-3 subunit beta Laminin-4 subunit beta Laminin-7 subunit beta Laminin-9 subunit beta S-laminin subunit beta
Q3USI2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 23 in total

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GO Term	Evidence Code	PMID
cell migration	IBA
neuron projection development	IDA	20566382
substrate adhesion-dependent cell spreading	IBA
positive regulation of cell adhesion	NAS	3794389
axon extension involved in regeneration	IMP	9396756

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

cell growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

basement membrane assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

synapse organization

neuromuscular junction development

extracellular structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

developmental process [inference]

anatomical structure morphogenesis [inference]

anatomical structure development [inference]

tissue development

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

growth [inference]

cell growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

developmental growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

developmental growth involved in morphogenesis [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
basement membrane	ISO
basement membrane	NAS	1678389
basement membrane	IDA	16041630 7670489
laminin-3 complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

laminin complex

laminin-3 complex

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion

cellular anatomical entity [inference]

extracellular region

synaptic cleft

cell junction [inference]

synapse

neuromuscular junction

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
integrin binding	IPI	20566382
extracellular matrix structural constituent	RCA	22159717 28071719
structural constituent of synapse-associated extracellular matrix	IEP	17189701
structural constituent of synapse-associated extracellular matrix	IDA	17189701
structural constituent of synapse-associated extracellular matrix	IMP	17189701

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

structural constituent of synapse-associated extracellular matrix

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Laminin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
animal organ morphogenesis
basement membrane assembly
cell migration
substrate adhesion-dependent cell spreading
tissue development

Displaying **all 2** entries
InterPro
Laminin, N-terminal
Laminin-type EGF domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060852	Pierson syndrome	Alliance of Genome Resources
DOID:2527	nephrosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	3912	WB:WBGene00002247
Homo sapiens	3913	Xenbase:XB-GENE-5935962	HUMAN70002
Caenorhabditis elegans	3914	WB:WBGene00002247
Caenorhabditis elegans	16777	WB:WBGene00002247
Xenopus tropicalis	16779	Xenbase:XB-GENE-5935962
Caenorhabditis elegans	22798	WB:WBGene00002247
Rattus norvegicus	25473	Xenbase:XB-GENE-5935962	RATNO41227
Xenopus tropicalis	177292	Xenbase:XB-GENE-5935962
Danio rerio	337767		DANRE24165
Pan troglodytes	460365		PANTR31116