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ligand of numb-protein X 1

Summary

Gene Symbol

Lnx1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16924

PubChem

16924

Alliance of Genome Resources

MGI:1278335

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transferase
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying **all 5** entries
UniProt	Protein Name
O70263	Ligand of Numb protein X 1 Ligand of Numb-binding protein 1 Numb-binding protein 1 RING-type E3 ubiquitin transferase LNX
E9Q4N3
Q3UUJ9
E9Q6Q0
A4QPD4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IBA IDA	11782429
synapse maturation	IDA IMP	30185604
protein ubiquitination	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

synapse maturation

developmental process [inference]

developmental maturation [inference]

synapse maturation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
postsynapse	IDA IEP IMP	30185604
hippocampal mossy fiber to CA3 synapse	IDA IMP	30185604
cytoplasm	IBA IDA	11782429

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

synapse [inference]

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

postsynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10551880 11922143 16410001 9535908
metal ion binding	IEA
identical protein binding	IPI	11922143
PDZ domain binding	IDA	9535908
ubiquitin-protein transferase activity	IBA IDA	11782429

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

binding [inference]

protein binding

protein domain specific binding [inference]

PDZ domain binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

E3 ubiquitin-protein ligase LNX

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
metal ion binding

Displaying **all 5** entries
InterPro
PDZ domain
PDZ superfamily
Zinc finger, RING-type, conserved site
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **122** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37629		FB:FBgn0001263
Drosophila melanogaster	43852		FB:FBgn0000008
Homo sapiens	84708		HGNC:6657	HUMAN75576
Rattus norvegicus	360926	10116_1:00442e	RGD:1308159	RATNO07899
Pan troglodytes	461322			PANTR33970
Canis lupus familiaris	475143			CANLF03392
Bos taurus	540694			BOVIN31489
Danio rerio	561226		ZFIN:ZDB-GENE-030131-9439	DANRE19622
Macaca mulatta	697862			MACMU36606
Monodelphis domestica	100017959			MONDO27408

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OrthoDB (Group)

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Acknowledgements