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latent transforming growth factor beta binding protein 3

Summary

Gene Symbol

Ltbp3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16998

PubChem

16998

Alliance of Genome Resources

MGI:1101355

Annotation

Keyword

Alternative splicing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Growth factor binding
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q61810

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
skeletal system development	IMP	12379497
chondrocyte differentiation	IMP	11790802
transforming growth factor beta receptor signaling pathway	ISO
transforming growth factor beta receptor signaling pathway	IMP	12379497
transforming growth factor beta receptor signaling pathway	IPI	7730318

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

multicellular organismal process [inference]

tissue remodeling [inference]

bone remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

bone morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

system development [inference]

skeletal system development

lung saccule development

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

negative regulation of multicellular organismal process [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of stem cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of mesenchymal stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

negative regulation of bone mineralization

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

regulation of stem cell proliferation [inference]

regulation of mesenchymal stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of stem cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of mesenchymal stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

regulation of bone mineralization [inference]

negative regulation of bone mineralization

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption [inference]

positive regulation of bone resorption

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of multicellular organismal process [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

negative regulation of bone mineralization

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IDA	7730318
extracellular matrix	ISA	7730318
collagen-containing extracellular matrix	ISO
collagen-containing extracellular matrix	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
transforming growth factor beta binding	ISO
transforming growth factor beta binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

transforming growth factor beta binding

cytokine binding [inference]

transforming growth factor beta binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

latent-transforming growth factor beta-binding

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090143	brachyolmia-amelogenesis imperfecta syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4054	Xenbase:XB-GENE-6050660	HUMAN07157
Xenopus tropicalis	16998	Xenbase:XB-GENE-6050660
Rattus norvegicus	83838		RATNO20483
Bos taurus	532772		BOVIN23455
Danio rerio	562912		DANRE37607
Monodelphis domestica	100030163		MONDO33187
Equus caballus	100146561		HORSE05348
Callithrix jacchus	100386336		CALJA04710
Pongo abelii	100458456		PONAB02338
Ailuropoda melanoleuca	100481909		AILME15429