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serpin family A member 10

Summary

Gene Symbol

Serpina10

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

171154

PubChem

171154

Alliance of Genome Resources

RGD:621220

Annotation

Keyword

Blood coagulation
Glycoprotein
Heparin-binding
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JEN8
Q62975	Regeneration-associated serpin 1 Serpin A10

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
regulation of acrosome reaction	ISO
negative regulation of endopeptidase activity	IBA
negative regulation of peptidase activity	IEA
liver regeneration	IEP	8670294
blood coagulation	IEA

GO Hierarchy

biological process

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration [inference]

liver regeneration

animal organ development [inference]

animal organ regeneration [inference]

liver regeneration

gland development [inference]

liver development [inference]

liver regeneration

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of reproductive process [inference]

regulation of acrosome reaction

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying **all 2** entries
GO Term	Evidence Code	PMID
heparin binding	IEA
serine-type endopeptidase inhibitor activity	IBA

GO Hierarchy

molecular function

binding [inference]

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

protein Z-dependent protease inhibitor

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
L: Replication, recombination and repair

Displaying **all 3** entries
Gene Ontology
blood coagulation
peptidase inhibitor activity
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Protein Z-dependent peptidase inhibitor, serpin domain
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2452	thrombophilia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **112** in total

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Drosophila melanogaster	40234		FB:FBgn0262057
Homo sapiens	51156		HGNC:15996	HUMAN20988
Mus musculus	217847	10090_1:003d18	MGI:2667725	MOUSE09071
Pan troglodytes	453130			PANTR09451
Bos taurus	517172			BOVIN16930
Danio rerio	565064		ZFIN:ZDB-GENE-041014-246
Macaca mulatta	700874			MACMU40098
Danio rerio	100003661		ZFIN:ZDB-GENE-100716-5	DANRE11878
Equus caballus	100064976			HORSE23176
Pongo abelii	100171989			PONAB08230