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solute carrier family 12 member 5

Summary

Gene Symbol

Slc12a5

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

171373

PubChem

171373

Alliance of Genome Resources

RGD:620811

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Chloride
Disulfide bond
Glycoprotein
Metal-binding
Phosphoprotein
Potassium transport
Reference proteome
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63633	Electroneutral potassium-chloride cotransporter 2 Furosemide-sensitive K-Cl cotransporter K-Cl cotransporter 2 Neuronal K-Cl cotransporter

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
ion transport	ISO
monoatomic ion transport	ISO
potassium ion transport	IDA	10942735 15175220 9374636
chloride transport	ISO
chloride transport	IDA	10942735 12040048 15175220 9374636

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cellular localization [inference]

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

thermosensory behavior

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

dendritic spine development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

potassium ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

inorganic ion homeostasis [inference]

chloride ion homeostasis

intracellular chloride ion homeostasis

potassium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hypotonic response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hypotonic response

response to temperature stimulus [inference]

thermosensory behavior

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

protein-containing complex localization [inference]

receptor localization to synapse [inference]

postsynaptic neurotransmitter receptor diffusion trapping

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

nitrogen compound transport [inference]

ammonium transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular localization [inference]

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor diffusion trapping

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
membrane	ISS
membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane [inference]

postsynaptic specialization membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

perikaryon

cell body [inference]

neuronal cell body

cell periphery

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GO Term	Evidence Code	PMID
protein binding	IPI	15094054 18769030
ammonium transmembrane transporter activity	IDA	15175220 16420452
chloride transmembrane transporter activity	ISO
potassium:chloride symporter activity	ISO
potassium:chloride symporter activity	IDA	10942735 11551954 12040048 15175220 22544747 9374636

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

ammonium transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:chloride symporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

ammonium transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:chloride symporter activity

chloride transmembrane transporter activity

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Solute carrier family 12 member

Functional Category

E: Amino acid transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
cell volume homeostasis
chemical synaptic transmission
chloride ion homeostasis
chloride transmembrane transport
chloride
monoatomic ion transport
potassium ion homeostasis
symporter activity

Displaying **all 4** entries
InterPro
Amino acid permease/ SLC12A domain
K/Cl co-transporter
SLC12A transporter family
SLC12A transporter, C-terminal

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
perikaryon	PMID:12967985
dendrite membrane	PMID:12967985

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	6560	FB:FBgn0261794
Drosophila melanogaster	9990	FB:FBgn0261794
Drosophila melanogaster	10723	FB:FBgn0261794
Drosophila melanogaster	20498	FB:FBgn0261794
Drosophila melanogaster	20499	FB:FBgn0261794
Drosophila melanogaster	29501	FB:FBgn0261794
Xenopus tropicalis	55719	Xenbase:XB-GENE-483436
Mus musculus	57138	Xenbase:XB-GENE-483436	MOUSE34018
Homo sapiens	57468	Xenbase:XB-GENE-483436	HUMAN57347
Drosophila melanogaster	107723	FB:FBgn0261794

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Acknowledgements