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transient receptor potential cation channel, subfamily M, member 8

Summary

Gene Symbol

Trpm8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

171382

PubChem

171382

Alliance of Genome Resources

MGI:2181435

Annotation

Keyword

3D-structure
Cell membrane
Coiled coil
Direct protein sequencing
Glycoprotein
Ion channel
Reference proteome
Sensory transduction
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8R4D5	Long transient receptor potential channel 6 Transient receptor potential p8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
calcium ion transport	IDA	17015441
intracellular calcium ion homeostasis	IDA	11893340
response to temperature stimulus	IDA	11893340
response to cold	IDA	12654248 17015441
response to cold	IMP	17481391 17481392 17538622

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of temperature stimulus [inference]

thermoception

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to cold

response to abiotic stimulus [inference]

response to temperature stimulus

response to cold

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

organic substance transport [inference]

calcium ion transport

calcium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO	25559186
plasma membrane	IBA
external side of plasma membrane	IDA	17015441
membrane	ISS	12654248
membrane	IDA	11893340

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

plasma membrane raft

membrane microdomain [inference]

membrane raft

plasma membrane raft

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
monoatomic ion channel activity	ISO
ion channel activity	ISO
monoatomic ion channel activity	IDA	11893340 15194687
ion channel activity	IDA	11893340 15194687
calcium channel activity	IDA	11893340 12654248 17015441

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transient receptor potential cation channel,subfamily m, member,

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ligand-gated calcium channel activity
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 2** entries
InterPro
Ion transport domain
TRPM, SLOG domain

Ortholog

Displaying entries **21 - 30** of 61 in total

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Species	Gene ID	Orthologous MAtrix
Saimiri boliviensis boliviensis	101027785	SAIBB27279
Felis catus	101101245	FELCA18072
Ovis aries	101104537	SHEEP00067
Gorilla gorilla gorilla	101148392	GORGO27258
Tursiops truncatus	101336865	TURTR13543
Dasypus novemcinctus	101446929	DASNO12991
Octodon degus	101568452	OCTDE15936
Jaculus jaculus	101612379	JACJA13792
Mustela putorius furo	101677005	MUSPF02652
Heterocephalus glaber	101709840	HETGA21732