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mahogunin, ring finger 1

Summary

Gene Symbol

Mgrn1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17237

PubChem

17237

Alliance of Genome Resources

MGI:2447670

Annotation

Keyword

Alternative splicing
Cell membrane
Cytoplasm
Endosome
Myristate
Nucleus
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D074	Mahogunin RING finger protein 1 RING-type E3 ubiquitin transferase MGRN1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
protein polyubiquitination	IDA	12560552
protein monoubiquitination	ISO
protein monoubiquitination	IEA
smoothened signaling pathway	IMP	32966817
heart development	IMP	32966817

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

vesicle-mediated transport [inference]

endosome to lysosome transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
ubiquitin ligase complex	IDA	32966817
ubiquitin ligase complex	IPI	32966817
nucleus	ISO
nucleus	IBA
nucleus	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	ISS
ubiquitin-protein transferase activity	ISO
protein binding	IPI	25342469 32966817 34486668
zinc ion binding	IEA
metal ion binding