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Guidelines

MIRAGE

Eukaryotic translation initiation factor 6

Summary

Gene Symbol

eif-6

Organism

Caenorhabditis elegans

External Links

NCBI Gene

173169

PubChem

173169

Alliance of Genome Resources

WB:WBGene00001234

Annotation

Keyword

Cytoplasm
Initiation factor
Nucleus
Reference proteome
Ribosome biogenesis

Proteins

Displaying 1 entry
UniProt	Protein Name
O62106

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
ribosomal subunit export from nucleus	IBA
maturation of 5.8S rRNA	IBA
maturation of LSU-rRNA	IBA
translation	IEA
translational initiation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular metabolic process [inference]

translational initiation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

protein metabolic process [inference]

translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular process [inference]

cellular metabolic process [inference]

translational initiation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

ribosome assembly [inference]

cytosolic ribosome assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

assembly of large subunit precursor of preribosome

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

ribosome assembly [inference]

cytosolic ribosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

assembly of large subunit precursor of preribosome

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

assembly of large subunit precursor of preribosome

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

localization [inference]

protein-containing complex localization [inference]

ribosomal subunit export from nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus

establishment of organelle localization [inference]

ribosomal subunit export from nucleus

organelle localization [inference]

ribosome localization [inference]

ribosomal subunit export from nucleus

establishment of organelle localization [inference]

ribosomal subunit export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing [inference]

miRNA-mediated post-transcriptional gene silencing

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleus	IEA
nucleolus	IEA
cytoplasm	IEA
cytosol	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

preribosome [inference]

preribosome, large subunit precursor

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
translation initiation factor activity	IEA
ribosome binding	IEA
ribosomal large subunit binding	IBA
ribosomal large subunit binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

ribosomal large subunit binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Translation initiation factor IF

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
assembly of large subunit precursor of preribosome
cytosolic ribosome assembly
maturation of 5.8S rRNA
maturation of LSU-rRNA
ribosomal large subunit binding
ribosomal large subunit biogenesis
ribosomal subunit export from nucleus

Displaying 1 entry
InterPro
Translation initiation factor IF6

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3692	Xenbase:XB-GENE-868337
Xenopus tropicalis	16418	Xenbase:XB-GENE-868337
Xenopus tropicalis	173169	Xenbase:XB-GENE-868337

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Last updated: December 8, 2025