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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Neprilysin-11
Summary
- Gene Symbol
-
- nep-11
- Organism
- Caenorhabditis elegans
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| O16796 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| protein processing |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| metal ion binding | ||
| metalloendopeptidase activity | ||
| metallopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- endothelin-converting enzyme
- Functional Category
-
- K: Transcription
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| hydrolase activity |
| metal ion binding |
| metalloendopeptidase activity |
| metallopeptidase activity |
| proteolysis |
| InterPro |
|---|
| Metallopeptidase, catalytic domain superfamily |
| Peptidase M13, C-terminal domain |
| Peptidase M13, N-terminal domain |
| Peptidase M13, domain 2 |
| Peptidase M13 |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050855 | renal fibrosis | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10763 | hypertension | |
| DOID:10825 | essential hypertension | |
| DOID:1184 | nephrotic syndrome | |
| DOID:12930 | dilated cardiomyopathy | |
| DOID:3021 | acute kidney failure | |
| DOID:3393 | coronary artery disease | |
| DOID:5844 | myocardial infarction | |
| DOID:6000 | congestive heart failure |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 1889 | HGNC:3146 | |||
| 9718 | HGNC:13275 | |||
| 31547 | FB:FBgn0029843 | |||
| 94204 | RGD:620293 | |||
| 107522 | MGI:1101356 | |||
| 230857 | MGI:1101357 | |||
| 408243 | RGD:1303039 | |||
| 560703 | ZFIN:ZDB-GENE-101112-2 | |||
| 777750 | ZFIN:ZDB-GENE-061110-100 | |||
| 793465 | ZFIN:ZDB-GENE-131120-140 |
