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Ephrin receptor 1

Summary

Gene Symbol

vab-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

173794

PubChem

173794

Alliance of Genome Resources

WB:WBGene00006868

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Developmental protein
Glycoprotein
Neurogenesis
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
O61460	Tyrosine-protein kinase Eph receptor Variable abnormal protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
oocyte maturation	IMP	12533508
protein phosphorylation	IEA
transmembrane receptor protein tyrosine kinase signaling pathway	IBA
nervous system development	IEA
axonogenesis	IMP	10409513

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ephrin receptor signaling pathway

cellular process involved in reproduction in multicellular organism [inference]

oocyte maturation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell maturation [inference]

oocyte maturation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte maturation

cellular process involved in reproduction in multicellular organism [inference]

oocyte maturation

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte maturation

anatomical structure morphogenesis [inference]

body morphogenesis [inference]

embryonic body morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

embryonic morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

oocyte maturation

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

system development [inference]

nervous system development

cellular developmental process [inference]

cell maturation [inference]

oocyte maturation

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of chemotaxis [inference]

regulation of axon guidance

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of axon guidance

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ephrin receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axon guidance

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GO Term	Evidence Code	PMID
plasma membrane	IDA	16267094 19853560
plasma membrane	IBA
plasma membrane	IEA
axon	IDA	9506518
receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

cell periphery

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GO Term	Evidence Code	PMID
protein kinase activity	IEA
protein tyrosine kinase activity	IDA	19853560
protein tyrosine kinase activity	IEA
transmembrane receptor protein tyrosine kinase activity	IBA
transmembrane receptor protein tyrosine kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

binding [inference]

protein binding

protein domain specific binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Eph receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
ephrin receptor activity
ephrin receptor signaling pathway
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway
transmembrane-ephrin receptor activity

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InterPro
Ephrin receptor ligand binding domain
Ephrin receptor type-A /type-B
Ephrin receptor, transmembrane domain
Fibronectin type III superfamily
Fibronectin type III
Galactose-binding-like domain superfamily
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
nucleus	PMID:19853560
plasma membrane	PMID:18472420 PMID:19853560
filamentous actin	PMID:16267094
axon	PMID:22383893 PMID:9506518
cell cortex	PMID:16267094
neuronal cell body	PMID:22383893

Ortholog

Displaying entries **11 - 20** of 37 in total

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	2050	Xenbase:XB-GENE-5881604
Danio rerio	2051	ZFIN:ZDB-GENE-100922-51
Danio rerio	13835	ZFIN:ZDB-GENE-990415-63
Danio rerio	13836	ZFIN:ZDB-GENE-990415-63
Xenopus tropicalis	13837	Xenbase:XB-GENE-6035245
Xenopus tropicalis	13838	Xenbase:XB-GENE-1015803
Homo sapiens	13839	HGNC:3389
Xenopus tropicalis	13841	Xenbase:XB-GENE-488635
Xenopus tropicalis	13842	Xenbase:XB-GENE-5915618
Danio rerio	13844	ZFIN:ZDB-GENE-070713-2