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Torsin-like protein

Summary

Gene Symbol

ooc-5

Organism

Caenorhabditis elegans

External Links

NCBI Gene

174433

PubChem

174433

Alliance of Genome Resources

WB:WBGene00003870

Annotation

Keyword

ATP-binding
Alternative splicing
Endoplasmic reticulum
Glycoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q95NU5	Abnormal oocyte formation protein 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cellular response to misfolded protein	IBA IDA	12554684
chaperone cofactor-dependent protein refolding	IEA

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

'de novo' protein folding [inference]

'de novo' post-translational protein folding [inference]

chaperone cofactor-dependent protein refolding

chaperone-mediated protein folding [inference]

chaperone cofactor-dependent protein refolding

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to topologically incorrect protein [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to misfolded protein [inference]

cellular response to misfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to misfolded protein [inference]

cellular response to misfolded protein

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

Displaying entries **1 - 5** of 10 in total

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2

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GO Term	Evidence Code	PMID
spindle	IDA	11714689
intracellular membrane-bounded organelle	IEA
endoplasmic reticulum lumen	IEA
plasma membrane	IDA	11714689
aster	IDA	11714689

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

perinuclear region of cytoplasm

supramolecular complex [inference]

aster

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ATP hydrolysis activity	IEA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Torsin

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ATP binding

Displaying **all 3** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Torsin-1A, C-terminal domain
Torsin

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
spindle	PMID:11714689
aster	PMID:11714689
endoplasmic reticulum	PMID:11714689
spindle pole	PMID:11714689
perinuclear region of cytoplasm	PMID:11714689
plasma membrane	PMID:11714689

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050836	focal dystonia	Alliance of Genome Resources
DOID:0060730	torsion dystonia 1	Alliance of Genome Resources
DOID:0080981	arthrogryposis multiplex congenita-5	Alliance of Genome Resources
DOID:543	dystonia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 25 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1861		HGNC:3098
Homo sapiens	27348		HGNC:11995
Homo sapiens	27433		HGNC:11996
Mus musculus	30931		MGI:1353568
Mus musculus	30934		MGI:1353605
Mus musculus	30935		MGI:1353652
Drosophila melanogaster	31399		FB:FBgn0025615
Homo sapiens	64222		HGNC:11997
Rattus norvegicus	266606		RGD:628863
Rattus norvegicus	304884		RGD:1310101

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024