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dynein axonemal heavy chain 5

Summary

Gene Symbol

DNAH5

Organism

Homo sapiens (human)

External Links

NCBI Gene

1767

PubChem

1767

Alliance of Genome Resources

HGNC:2950

Annotation

Keyword

3D-structure
ATP-binding
Cilium
Coiled coil
Cytoskeleton
Disease variant
Dynein
Kartagener syndrome
Microtubule
Motor protein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TE73	Axonemal beta dynein heavy chain 5 Ciliary dynein heavy chain 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cilium movement	IMP	11062149 15750039 16627867 23261302
epithelial cilium movement involved in extracellular fluid movement	IEA
determination of left/right symmetry	IMP	11788826 17515466 22499950
heart development	IEA
lateral ventricle development	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement

epithelial cilium movement involved in extracellular fluid movement

cilium movement involved in cell motility

flagellated sperm motility

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

outer dynein arm assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

outer dynein arm assembly

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

multicellular organismal process [inference]

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

developmental process [inference]

anatomical structure development [inference]

lateral ventricle development

animal organ development [inference]

heart development

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement

establishment of localization in cell

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	IDA	29916806
microtubule	IEA
axoneme	IDA	15750039 16492982 18950741 23849778 24203976 26387594 26909801 29916806 31178125
motile cilium	IDA	31178125

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex [inference]

axonemal dynein complex [inference]

outer dynein arm

catalytic complex [inference]

dynein complex [inference]

axonemal dynein complex [inference]

outer dynein arm

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

glial cell projection

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ATP binding	IEA
minus-end-directed microtubule motor activity	IBA
ATP hydrolysis activity	IEA
dynein intermediate chain binding	IBA
dynein light intermediate chain binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dyneins heavy chain

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
dynein intermediate chain binding
dynein light intermediate chain binding
microtubule-based movement
minus-end-directed microtubule motor activity

Displaying **all 9** entries
InterPro
Dynein heavy chain 3, AAA+ lid domain
Dynein heavy chain, AAA module D4
Dynein heavy chain, ATP-binding dynein motor region
Dynein heavy chain, coiled coil stalk
Dynein heavy chain, hydrolytic ATP-binding dynein motor region
Dynein heavy chain, linker
Dynein heavy chain, tail
Dynein heavy chain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050144	Kartagener syndrome	Alliance of Genome Resources
DOID:0110599	primary ciliary dyskinesia 3	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 69 in total

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Species	Gene ID	Orthologous MAtrix
Carlito syrichta	103261454	CARSF20762
Cynoglossus semilaevis	103388235	CYNSE06034
Ursus maritimus	103662236	URSMA20273
Rhinopithecus roxellana	104670757	RHIRO06618
Esox lucius	105006127	ESOLU61607
Macaca nemestrina	105492325	MACNE37759
Mandrillus leucophaeus	105549581	MANLE23739
Cercocebus atys	105585944	CERAT15811
Aotus nancymaae	105732992	AOTNA03797
Microcebus murinus	105885375	MICMU15004

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Acknowledgements