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Annotation

Keyword

ATP-binding
DNA repair
DNA-binding
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P13705	Protein repair-1 Protein repair-3
A0A087WQ16
E9QPY6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
maintenance of DNA repeat elements	ISO
DNA repair	ISO
mitotic recombination	IBA
somatic recombination of immunoglobulin gene segments	IBA IMP	15238604
mismatch repair	IBA IGI IMP ISO	10706084 11691815 16728433

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic diversification of immune receptors via somatic mutation [inference]

somatic hypermutation of immunoglobulin genes

somatic diversification of immunoglobulins [inference]

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

maintenance of DNA repeat elements

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of molecular function [inference]

regulation of ATP-dependent activity [inference]

positive regulation of ATP-dependent activity [inference]

positive regulation of helicase activity

regulation of helicase activity [inference]

positive regulation of helicase activity

positive regulation of molecular function [inference]

positive regulation of ATP-dependent activity [inference]

positive regulation of helicase activity

positive regulation of catalytic activity [inference]

positive regulation of helicase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of helicase activity

regulation of helicase activity [inference]

positive regulation of helicase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
MutSbeta complex	ISO
nucleus	IBA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

mismatch repair complex [inference]

MutSbeta complex

nuclear protein-containing complex [inference]

MutSbeta complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
single guanine insertion binding	ISO
DNA binding	IGI	10545954
enzyme binding	ISO
dinucleotide repeat insertion binding	ISO
single-stranded DNA binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

binding [inference]

protein binding [inference]

enzyme binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

damaged DNA binding

double-stranded DNA binding

mismatched DNA binding

DNA insertion or deletion binding [inference]

single base insertion or deletion binding [inference]

single guanine insertion binding

dinucleotide insertion or deletion binding

dinucleotide repeat insertion binding

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

small molecule sensor activity [inference]

DNA damage sensor activity [inference]

ATP-dependent DNA damage sensor activity

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

DNA mismatch repair protein Msh3

Functional Category

C: Energy production and conversion
K: Transcription
L: Replication, recombination and repair
V: Defense mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
ATP-dependent DNA damage sensor activity
DNA repair
double-stranded DNA binding
mitotic recombination
nucleotide binding
somatic recombination of immunoglobulin gene segments

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:0080412	familial adenomatous polyposis 4	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:2871	endometrial carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **101** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4437		HGNC:7326	HUMAN79873
Canis lupus familiaris	479164			CANLF11912
Rattus norvegicus	499505	10116_1:001093	RGD:1563954
Danio rerio	565400		ZFIN:ZDB-GENE-060526-307	DANRE37151
Bos taurus	616744			BOVIN33906
Macaca mulatta	711187			MACMU39528
Pan troglodytes	735384			PANTR35193
Saccharomyces cerevisiae S288C	850454		SGD:S000000688
Monodelphis domestica	100015958			MONDO17501
Equus caballus	100073255			HORSE08730

GlyTouCan

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OrthoDB (Group)

International Collaboration

Acknowledgements