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Guidelines

MIRAGE

mutS homolog 3

Summary

Gene Symbol

Msh3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17686

PubChem

17686

Alliance of Genome Resources

MGI:109519

Annotation

Keyword

ATP-binding
DNA repair
DNA-binding
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P13705	Protein repair-1 Protein repair-3
E9QPY6
A0A087WQ16

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
DNA repair	ISO
mismatch repair	ISO
mismatch repair	IMP	10706084 16728433
mismatch repair	IGI	10706084 11691815 16728433
mismatch repair	IBA

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic diversification of immune receptors via somatic mutation [inference]

somatic hypermutation of immunoglobulin genes

somatic diversification of immunoglobulins [inference]

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

DNA recombination [inference]

mitotic recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

maintenance of DNA repeat elements

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

mismatch repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

maintenance of DNA repeat elements

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

mismatch repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

mismatch repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of molecular function [inference]

regulation of ATP-dependent activity [inference]

positive regulation of ATP-dependent activity [inference]

positive regulation of helicase activity

regulation of helicase activity [inference]

positive regulation of helicase activity

positive regulation of molecular function [inference]

positive regulation of ATP-dependent activity [inference]

positive regulation of helicase activity

positive regulation of catalytic activity [inference]

positive regulation of helicase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of helicase activity

regulation of helicase activity [inference]

positive regulation of helicase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IBA
MutSbeta complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

mismatch repair complex [inference]

MutSbeta complex

nuclear protein-containing complex [inference]

MutSbeta complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
DNA binding	IGI	10545954
damaged DNA binding	IGI	10545954
double-stranded DNA binding	IBA
single-stranded DNA binding	ISO
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

binding [inference]

protein binding [inference]

enzyme binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

damaged DNA binding

double-stranded DNA binding

mismatched DNA binding

DNA insertion or deletion binding [inference]

single base insertion or deletion binding [inference]

single guanine insertion binding

dinucleotide insertion or deletion binding

dinucleotide repeat insertion binding

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

small molecule sensor activity [inference]

DNA damage sensor activity [inference]

ATP-dependent DNA damage sensor activity

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA mismatch repair protein

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
ATP-dependent DNA damage sensor activity
DNA repair
nucleotide binding

Displaying entries **1 - 10** of 11 in total

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InterPro
DNA mismatch repair MutS family
DNA mismatch repair protein MutS, C-terminal
DNA mismatch repair protein MutS, N-terminal
DNA mismatch repair protein MutS, clamp
DNA mismatch repair protein MutS, connector domain
DNA mismatch repair protein MutS, core domain superfamily
DNA mismatch repair protein MutS, core
DNA mismatch repair protein MutS-like, N-terminal
DNA mismatch repair protein MutS/MSH
MutS, connector domain superfamily

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026