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Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase

Summary

Gene Symbol

asm-3

Organism

Caenorhabditis elegans

External Links

NCBI Gene

176879

PubChem

176879

Alliance of Genome Resources

WB:WBGene00000213

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosidase
Metal-binding
Proteomics identification
Reference proteome
Secreted
Signal
Sphingolipid metabolism
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
G8JY85
Q9UAY4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ceramide biosynthetic process	IBA ISS
lipid droplet disassembly	IMP	26773047
sphingomyelin catabolic process	IBA IEA ISS
sphingolipid metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

lipid droplet disassembly

organelle disassembly [inference]

lipid droplet disassembly

cellular component disassembly [inference]

organelle disassembly [inference]

lipid droplet disassembly

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IEA ISS
lysosome	IBA
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hydrolase activity	IEA
metal ion binding	IEA
acid sphingomyelin phosphodiesterase activity	IBA
hydrolase activity, acting on glycosyl bonds	IEA
sphingomyelin phosphodiesterase activity	IEA ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

sphingomyelin phosphodiesterase activity

acid sphingomyelin phosphodiesterase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

sphingomyelin phosphodiesterase activity

acid sphingomyelin phosphodiesterase activity

hydrolase activity, acting on glycosyl bonds

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sphingomyelin phosphodiesterase

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
acid sphingomyelin phosphodiesterase activity
ceramide biosynthetic process
hydrolase activity
metal ion binding
sphingomyelin catabolic process

Displaying **all 4** entries
InterPro
Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain
Calcineurin-like phosphoesterase domain, ApaH type
Metallo-dependent phosphatase-like
Sphingomyelin phosphodiesterase

Rhea

RHEA:19253

H₂O + a sphingomyelin

H⁺ + phosphocholine + an N-acylsphing-4-enine

Enzyme

3.1.4.12

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0070111	Niemann-Pick disease type A	Alliance of Genome Resources
DOID:0070112	Niemann-Pick disease type B	Alliance of Genome Resources
DOID:14504	Niemann-Pick disease	Alliance of Genome Resources
DOID:893	Wilson disease	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP008210
Gene Name: Protein ASM-3

Ortholog

Displaying **all 10** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	6609		HGNC:11120
Mus musculus	20597		MGI:98325
Drosophila melanogaster	37884		FB:FBgn0034997
Rattus norvegicus	308909		RGD:1549719
Danio rerio	556700		ZFIN:ZDB-GENE-110411-222
Necator americanus	25345711	51031_0:004a40
Necator americanus	25359300	51031_0:003d97
Strongyloides ratti	36375960	34506_0:0009b7
Strongyloides ratti	36380417	34506_0:001fe1
Xenopus tropicalis	100487433		Xenbase:XB-GENE-997694

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements