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Ephrin-4

Summary

Gene Symbol

efn-4

Organism

Caenorhabditis elegans

External Links

NCBI Gene

176882

PubChem

176882

Alliance of Genome Resources

WB:WBGene00001165

Annotation

Keyword

Cell membrane
Developmental protein
Disulfide bond
GPI-anchor
Neurogenesis
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O44516	Protein male abnormal 26

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
morphogenesis of embryonic epithelium	IGI IMP	12403719
regulation of cell adhesion	IGI IMP	12679110
ephrin receptor signaling pathway	IBA
nematode male tail tip morphogenesis	IGI IMP	12679110
cell migration involved in gastrulation	IGI IMP	12403719

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

cell migration involved in gastrulation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

developmental process [inference]

developmental process involved in reproduction [inference]

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of chemotaxis [inference]

regulation of axon guidance

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of axon guidance

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axon guidance

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IEA
neuronal cell body	IDA	12403719
plasma membrane	IBA IEA
side of membrane	IEA
axon	IDA	12403719

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

cell body [inference]

neuronal cell body

side of membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26903502
ephrin receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

ephrin receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ephrin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ephrin receptor binding
ephrin receptor signaling pathway

Displaying **all 4** entries
InterPro
Cupredoxin
Ephrin receptor-binding domain
Ephrin, conserved site
Ephrin

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
neuronal cell body	PMID:12403719
axon	PMID:12403719

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060668	anencephaly	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:14737	craniofrontonasal syndrome	Alliance of Genome Resources
DOID:1934	dysostosis	Alliance of Genome Resources
DOID:9778	irritable bowel syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 33 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	1942	HGNC:3221
Homo sapiens	1943	HGNC:3222
Homo sapiens	1944	HGNC:3223
Homo sapiens	1945	HGNC:3224
Homo sapiens	1946	HGNC:3225
Homo sapiens	1947	HGNC:3226
Mus musculus	13636	MGI:103236
Mus musculus	13637	MGI:102707
Mus musculus	13638	MGI:106644
Mus musculus	13639	MGI:106643

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements