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Standards Ontologies Notations
aggrecan

Summary
Gene Symbol
  • ACAN
Aliases
  • CSPGCP
  • aggrecan proteoglycan
Organism
Homo sapiens (human)
External Links
NCBI Gene
176
HGNC
319
KEGG Gene ID
hsa:176
PubChem
176
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Dwarfism
  • EGF-like domain
  • Extracellular matrix
  • Immunoglobulin domain
  • Lectin
  • Metal-binding
  • Proteoglycan
  • Reference proteome
  • Repeat
  • Signal
  • Sushi
Proteins
Displaying 1 entry
UniProt Protein Name
P16112
  • Cartilage-specific proteoglycan core protein
  • Chondroitin sulfate proteoglycan core protein 1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entry 6 - 6 of 6 in total
GO Term Evidence Code PMID
cell adhesion
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
Human Protein Atlas
ENSG00000157766

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas
KEGG BRITE Database
Orthology
K06792
Name
aggrecan 1
References
Disease
Disease Ontology
Displaying entries 161 - 170 of 183 in total
DO ID Disease Name Source
DOID:6457 Cowden syndrome
DOID:65 connective tissue disease
DOID:6590 spondylitis
DOID:6688 autoimmune lymphoproliferative syndrome
DOID:6713 cerebrovascular disease
DOID:676 juvenile rheumatoid arthritis
DOID:684 hepatocellular carcinoma
DOID:7148 rheumatoid arthritis
DOID:758 situs inversus
DOID:786 laryngeal disease
The Human Phenotype Ontology
Displaying entries 1 - 10 of 48 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000007 Autosomal recessive inheritance
HP:0000272 Malar flattening
HP:0000303 Mandibular prognathia
HP:0000358 Posteriorly rotated ears
HP:0000368 Low-set, posteriorly rotated ears
HP:0000369 Low-set ears
HP:0000470 Short neck
HP:0000926 Platyspondyly
HP:0001156 Brachydactyly
Displaying all 6 entries
Disease ID Disease Name
ORPHA:171866
  • spondyloepimetaphyseal dysplasia, aggrecan type
ORPHA:435804
  • short stature-advanced bone age-early-onset osteoarthritis syndrome
OMIM:608361
  • spondyloepiphyseal dysplasia, Kimberley type
OMIM:165800
  • short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans
OMIM:612813
  • spondyloepimetaphyseal dysplasia, aggrecan type
ORPHA:93283
  • spondyloepiphyseal dysplasia, Kimberley type
PubChem Disease
GHR Health Conditions
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
Ortholog
Displaying entries 41 - 45 of 45 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
108535782 RHIBE19388
104661607 RHIRO28613
116450302 CORMO03088
103273187 CARSF02287
115613125 STRHB23096
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024