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cytochrome c oxidase subunit I

Summary

Gene Symbol

COX1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17708

PubChem

17708

Alliance of Genome Resources

MGI:102504

Annotation

Keyword

3D-structure
Calcium
Copper
Heme
Magnesium
Mitochondrion inner membrane
Oxidoreductase
Reference proteome
Respiratory chain
Sodium
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9MD68
P00397	Cytochrome c oxidase polypeptide I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
aerobic respiration	IBA
mitochondrial electron transport, cytochrome c to oxygen
oxidative phosphorylation	IEA
electron transport coupled proton transport
response to hypoxia	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

oxidative phosphorylation

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

oxidative phosphorylation

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

developmental process [inference]

anatomical structure development [inference]

cerebellum development

response to stimulus [inference]

response to stress [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to copper ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrial membrane	ISO
mitochondrial respiratory chain complex IV
mitochondrial inner membrane	IDA	16815968
respiratory chain complex III	ISO
mitochondrion	HDA IDA	11940593 12943672 15582606 16103131 16336229 18614015 19837698 26644517

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

respiratory chain complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

respiratory chain complex IV

mitochondrial respiratory chain complex IV

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

respiratory chain complex IV

mitochondrial respiratory chain complex IV

oxidoreductase complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

transporter complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
heme binding	IEA
cytochrome-c oxidase activity	IDA ISO ISS	18729827

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

cytochrome-c oxidase activity

oxidoreductase activity, acting on a heme group of donors [inference]

cytochrome-c oxidase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cytochrome c oxidase subunit I

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism

Displaying **all 7** entries
Gene Ontology
aerobic respiration
cytochrome-c oxidase activity
electron transport coupled proton transport
heme binding
metal ion binding
mitochondrial electron transport, cytochrome c to oxygen
oxidative phosphorylation

Displaying **all 5** entries
InterPro
Cytochrome c oxidase subunit I domain
Cytochrome c oxidase subunit I
Cytochrome c oxidase, subunit I, copper-binding site
Cytochrome c oxidase-like, subunit I domain
Cytochrome c oxidase-like, subunit I superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:3762	cytochrome-c oxidase deficiency disease	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4512		HGNC:7419	HUMAN99524
Rattus norvegicus	26195	10116_1:0057c3	RGD:621871	RATNO44115
Danio rerio	140539		ZFIN:ZDB-GENE-011205-14	DANRE45623
Drosophila melanogaster	192469		FB:FBgn0013674
Kryptolebias marmoratus	804465			KRYMA29338
Canis lupus familiaris	804478			CANLF19487
Vombatus ursinus	804526			VOMUR32450
Ursus maritimus	804864			URSMA33573
Ictalurus punctatus	804884			ICTPU00324
Esox lucius	806651			ESOLU00483