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Guidelines

MIRAGE

deoxyribonuclease 2, lysosomal

Summary

Gene Symbol

DNASE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1777

PubChem

1777

Alliance of Genome Resources

HGNC:2960

Annotation

Keyword

Alternative splicing
Apoptosis
Developmental protein
Disease variant
Disulfide bond
Endonuclease
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O00115	Acid DNase Deoxyribonuclease II alpha Lysosomal DNase II R31240_2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
DNA metabolic process	TAS	9714827
apoptotic DNA fragmentation	IBA
enucleate erythrocyte differentiation	IEA
regulation of immune response	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process

DNA catabolic process [inference]

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation [inference]

enucleate erythrocyte differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation [inference]

enucleate erythrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of response to stimulus [inference]

regulation of immune response

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lysosome	IEA
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
DNA binding	TAS	9714827
deoxyribonuclease II activity	IBA
protein binding	IPI	28514442 33961781

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Deoxyribonuclease-2

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
deoxyribonuclease II activity
hydrolase activity

Displaying 1 entry
InterPro
Deoxyribonuclease II

Ortholog

Displaying entries **41 - 50** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Carlito syrichta	103249401		CARSF22644
Ursus maritimus	103682150		URSMA30001
Nannospalax galili	103751880		NANGA16770
Rhinopithecus roxellana	104661085		RHIRO03222
Pteropus vampyrus	105307170		PTEVA06317
Aotus nancymaae	105705927		AOTNA13435
Propithecus coquereli	105807868		PROCO20348
Microcebus murinus	105885498		MICMU07066
Dipodomys ordii	105999245		DIPOR22902
Equus asinus asinus	106844341		EQUAS28935

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025