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Glucose-6-phosphate 1-dehydrogenase

Summary

Gene Symbol

gspd-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

178046

PubChem

178046

Alliance of Genome Resources

WB:WBGene00007108

Annotation

Keyword

Cytoplasm
Glucose metabolism
NADP
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q27464

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
NADP metabolic process	ISS
pentose-phosphate shunt, oxidative branch	IBA
pentose-phosphate shunt	IEA
glucose metabolic process	IBA IEA
glucose 6-phosphate metabolic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

NADPH regeneration [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

glucose 6-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

glucose 6-phosphate metabolic process

carbohydrate derivative metabolic process [inference]

glucose 6-phosphate metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

NADPH regeneration [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

glucose 6-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NADPH regeneration [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IBA IEA
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
NADP binding	IEA
oxidoreductase activity	IEA
glucose-6-phosphate dehydrogenase activity	IBA IEA ISS
oxidoreductase activity, acting on CH-OH group of donors	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

glucose-6-phosphate dehydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glucose-6-phosphate 1-dehydrogenase 1

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
NADP binding
glucose metabolic process
glucose-6-phosphate dehydrogenase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity
pentose-phosphate shunt, oxidative branch
pentose-phosphate shunt

Displaying **all 5** entries
InterPro
Glucose-6-phosphate dehydrogenase, C-terminal
Glucose-6-phosphate dehydrogenase, NAD-binding
Glucose-6-phosphate dehydrogenase, active site
Glucose-6-phosphate dehydrogenase
NAD(P)-binding domain superfamily

Disease

Disease Ontology

Displaying entries **11 - 20** of 24 in total

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DO ID	Disease Name	Source
DOID:2383	neonatal jaundice	Alliance of Genome Resources
DOID:2861	congenital nonspherocytic hemolytic anemia	Alliance of Genome Resources
DOID:557	kidney disease	Alliance of Genome Resources
DOID:583	hemolytic anemia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6713	cerebrovascular disease	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:9279	hyperhomocysteinemia	Alliance of Genome Resources
DOID:9281	phenylketonuria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 12 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	2539		HGNC:4057
Mus musculus	14380		MGI:105977
Mus musculus	14381		MGI:105979
Rattus norvegicus	24377		RGD:2645
Drosophila melanogaster	32974		FB:FBgn0004057
Drosophila melanogaster	40445		FB:FBgn0037147
Danio rerio	570579		ZFIN:ZDB-GENE-070508-4
Saccharomyces cerevisiae S288C	855480		SGD:S000005185
Brugia malayi	6102236	6279_0:002734
Loa loa	9942358	7209_0:00103d

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements