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Erlin

Summary

Gene Symbol

erl-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

178178

PubChem

178178

Alliance of Genome Resources

WB:WBGene00016592

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A3QMC6	Endoplasmic reticulum lipid raft-associated protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
SREBP signaling pathway	IBA
ERAD pathway	IMP	22269071

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to stimulus [inference]

response to stress [inference]

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to sterol depletion [inference]

SREBP signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	IEA
protein-containing complex	IMP	22269071
endoplasmic reticulum membrane	IBA IDA IEA	22269071
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cholesterol binding	IBA
ubiquitin protein ligase binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cholesterol binding
ubiquitin protein ligase binding

Displaying **all 3** entries
InterPro
Band 7 domain
Band 7/SPFH domain superfamily
Erlin1/2

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cytoplasm	PMID:22269071

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110771	hereditary spastic paraplegia 18	Alliance of Genome Resources
DOID:0110813	hereditary spastic paraplegia 62	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 13 in total

1

2

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10613		HGNC:16947
Homo sapiens	11160		HGNC:1356
Mus musculus	226144		MGI:2387613
Mus musculus	244373		MGI:2387215
Rattus norvegicus	290823		RGD:1309010
Rattus norvegicus	293939		RGD:1307058
Danio rerio	541490		ZFIN:ZDB-GENE-050327-13
Xenopus tropicalis	549473		Xenbase:XB-GENE-950144
Xenopus tropicalis	549646		Xenbase:XB-GENE-5794201
Brugia malayi	6095500	6279_0:002949

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024