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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

Autophagy-related protein 18

Summary

Gene Symbol

atg-18

Organism

Caenorhabditis elegans

External Links

NCBI Gene

179246

PubChem

179246

Alliance of Genome Resources

WB:WBGene00018294

Annotation

Keyword

Alternative splicing
Autophagy
Cytoplasm
Cytoplasmic vesicle
Lipid-binding
Membrane
Reference proteome
Repeat
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
O16466

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
autophagy of mitochondrion	IBA
pexophagy	IBA
plasma membrane repair	IMP	27875098
autophagy	IGI	12958363
autophagy	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome [inference]

pexophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome [inference]

pexophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

cell death [inference]

programmed cell death

cell population proliferation [inference]

germ cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

cellular process involved in reproduction in multicellular organism [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome [inference]

pexophagy

cell division [inference]

stem cell division [inference]

germ-line stem cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to toxic substance

process utilizing autophagic mechanism [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome [inference]

pexophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion

organelle disassembly [inference]

autophagy of mitochondrion

cellular component disassembly [inference]

organelle disassembly [inference]

autophagy of mitochondrion

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane repair

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

multicellular organismal process [inference]

multicellular organism development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

embryo development [inference]

embryo development ending in birth or egg hatching

determination of adult lifespan

post-embryonic development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis

anatomical structure development [inference]

multicellular organism development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

embryo development [inference]

embryo development ending in birth or egg hatching

response to stimulus [inference]

response to chemical [inference]

response to toxic substance [inference]

cellular response to toxic substance

cellular response to chemical stimulus [inference]

cellular response to toxic substance

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to toxic substance

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

import into cell [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	25124690
cytoplasm	IEA
cytosol	IBA
membrane	IEA
extrinsic component of membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

phagophore assembly site membrane

extrinsic component of membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endocytic vesicle [inference]

phagocytic vesicle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
lipid binding	IEA
phosphatidylinositol-5-phosphate binding	IDA	21802374
protein-macromolecule adaptor activity	IBA
phosphatidylinositol-3-phosphate binding	IDA	21802374
phosphatidylinositol-3-phosphate binding	IBA

GO Hierarchy

molecular function

binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cytoplasm	PMID:25124690

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12858	Huntington's disease	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026