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Dopamine receptor 2

Summary

Gene Symbol

dop-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

179347

KEGG Gene ID

PubChem

179347

Alliance of Genome Resources

WB:WBGene00001053

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
E7EM37	Dopamine D2-like receptor dop-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
synaptic transmission, dopaminergic	IEA
G protein-coupled receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
G protein-coupled dopamine receptor signaling pathway	IMP
G protein-coupled dopamine receptor signaling pathway	IGI

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, dopaminergic

signal transduction [inference]

G protein-coupled receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nicotine

cellular response to nitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

mating behavior [inference]

male mating behavior [inference]

multicellular organismal process [inference]

behavior [inference]

reproductive behavior [inference]

mating behavior [inference]

male mating behavior [inference]

response to stimulus [inference]

response to nutrient levels [inference]

response to food

response to chemical [inference]

response to food

response to nicotine [inference]

cellular response to nicotine

cellular response to chemical stimulus [inference]

cellular response to nicotine

cellular response to nitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

response to nitrogen compound [inference]

response to amine [inference]

response to amphetamine [inference]

cellular response to amphetamine

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nicotine

cellular response to nitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of neuronal signal transduction

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, dopaminergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of locomotion involved in locomotory behavior

positive regulation of locomotion [inference]

positive regulation of locomotion involved in locomotory behavior

regulation of locomotion involved in locomotory behavior [inference]

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of locomotion involved in locomotory behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of reproductive process [inference]

positive regulation of male mating behavior

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of locomotion involved in locomotory behavior

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of neuronal signal transduction

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of neuronal signal transduction

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

positive regulation of behavior [inference]

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

regulation of locomotion involved in locomotory behavior [inference]

regulation of male mating behavior

positive regulation of male mating behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

regulation of reproductive process [inference]

regulation of male mating behavior

positive regulation of male mating behavior

positive regulation of reproductive process [inference]

positive regulation of male mating behavior

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
plasma membrane	IEA
membrane	IEA
dendrite	IBA
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP
G protein-coupled receptor activity	IEA
G protein-coupled serotonin receptor activity	IBA
protein binding	IPI
neurotransmitter receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

neurotransmitter receptor activity

postsynaptic neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity, coupled via Gi/Go

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
cytoplasm	PMID:12887685
nucleus	PMID:12887685

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	1814	HGNC:3024
Homo sapiens	1813	HGNC:3023
Mus musculus	13490	MGI:94925
Mus musculus	13489	MGI:94924
Rattus norvegicus	24318	RGD:2520
Rattus norvegicus	29238	RGD:2521