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neural cell adhesion molecule 1

Summary

Gene Symbol

Ncam1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17967

PubChem

17967

Alliance of Genome Resources

MGI:97281

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Direct protein sequencing
Disulfide bond
GPI-anchor
Heparin-binding
Immunoglobulin domain
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
E9Q589
A0A0A6YY47
E9QB01
P13595

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 23 in total

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GO Term	Evidence Code	PMID
thalamus development	ISO
neuron projection development	IGI	21389209
multicellular organismal response to stress	ISO
homotypic cell-cell adhesion	IMP	7613634
response to cocaine	ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

homotypic cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition

cell development [inference]

neuron development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance [inference]

commissural neuron axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

multicellular organismal response to stress

developmental process [inference]

anatomical structure development [inference]

thalamus development

cell development [inference]

neuron development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition

cell development [inference]

neuron development

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to organic cyclic compound [inference]

response to cocaine

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to alcohol [inference]

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

response to inorganic substance [inference]

response to metal ion [inference]

response to lead ion

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to oxygen-containing compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to salt [inference]

response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of semaphorin-plexin signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of vesicle docking [inference]

regulation of exocyst assembly

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of semaphorin-plexin signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of semaphorin-plexin signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

regulation of programmed cell death [inference]

negative regulation of programmed cell death

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of exocyst assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

negative regulation of cellular process [inference]

negative regulation of programmed cell death

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of exocyst assembly

regulation of vesicle docking [inference]

regulation of exocyst assembly

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

Displaying entries **6 - 10** of 18 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	ISO	17213291
external side of plasma membrane	IDA	17213291 21708977 7613634
cell surface	ISO
axon	IDA	15065125 15738425 15964824 24582971
growth cone	IDA	21389209

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

anchoring junction [inference]

cell-cell junction

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

myelin sheath

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10772929 21389209 26651291 28098160 35771867
heparin binding	IEA
phosphatase binding	ISO
LRR domain binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

phosphatase binding

protein domain specific binding [inference]

LRR domain binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

neural cell adhesion molecule 1-A

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **11 - 20** of 77 in total

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Species	Gene ID	Orthologous MAtrix
Pan troglodytes	466782	PANTR04345
Canis lupus familiaris	479435	CANLF15281
Felis catus	493956	FELCA24216
Macaca mulatta	693789	MACMU11106
Monodelphis domestica	100032207	MONDO21359
Equus caballus	100062164	HORSE38931
Ornithorhynchus anatinus	100085373	ORNAN03203
Taeniopygia guttata	100226293	TAEGU14054
Callithrix jacchus	100398755	CALJA05048
Pongo abelii	100439394	PONAB03989

GlyTouCan

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LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements