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NPC intracellular cholesterol transporter 1 homolog 1

Summary

Gene Symbol

ncr-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

180719

PubChem

180719

Alliance of Genome Resources

WB:WBGene00003561

Annotation

Keyword

Developmental protein
Disulfide bond
Glycoprotein
Lipid transport
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q19127	Niemann-Pick C1 protein homolog 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
intestinal cholesterol absorption	IBA
cholesterol transport	IMP	10801441
positive regulation of growth rate	IMP	10801441
dauer larval development	IGI	10801441
cholesterol homeostasis	IBA IMP	10801441

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

multicellular organism development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

post-embryonic development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport

sterol transport

cholesterol transport

intestinal cholesterol absorption

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport

intestinal cholesterol absorption

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of growth rate [inference]

positive regulation of growth rate

positive regulation of growth [inference]

positive regulation of growth rate

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of growth rate

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of egg-laying behavior

regulation of reproductive process [inference]

regulation of egg-laying behavior

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	IEA
late endosome	ISS	9990080
plasma membrane	IBA
lysosome	ISS	9990080

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cholesterol binding	IBA
molecular_function	ND

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

patched

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Protein patched/dispatched
Sterol-sensing domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070113	Niemann-Pick disease type C1	Alliance of Genome Resources
DOID:14504	Niemann-Pick disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 17 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	4864	HGNC:7897
Mus musculus	18145	MGI:1097712
Homo sapiens	29881	HGNC:7898
Drosophila melanogaster	33072	FB:FBgn0261675
Drosophila melanogaster	34358	FB:FBgn0024320
Mus musculus	237636	MGI:2685089
Rattus norvegicus	266732	RGD:628693
Rattus norvegicus	432367	RGD:1303135
Danio rerio	553330	ZFIN:ZDB-GENE-030131-3161
Saccharomyces cerevisiae S288C	856101	SGD:S000005927

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements