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dihydropyrimidinase like 2

Summary

Gene Symbol

DPYSL2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1808

PubChem

1808

Alliance of Genome Resources

HGNC:3014

Annotation

Keyword

3D-structure
Alternative splicing
Cytoskeleton
Developmental protein
Differentiation
Direct protein sequencing
Membrane
Methylation
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
S-nitrosylation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A1C7CYX9
Q16555	Collapsin response mediator protein 2 N2A3 Unc-33-like phosphoprotein 2
Q59GB4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
nucleobase-containing compound metabolic process	TAS	8973361
pyrimidine nucleobase catabolic process	IBA
endocytosis	IMP	20801876
cytoskeleton organization	ISS
signal transduction	TAS	8973361

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

endocytosis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular developmental process [inference]

cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA	20801876
cytosol	IBA
cytoskeleton
microtubule	IDA	20801876

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton

microtubule cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
dihydropyrimidinase activity	IBA
protein binding	IPI	16260607 19235893 21900206 24722188 25416956 28514442 29892012 31515488 32296183 32814053 33961781 36950384
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA
identical protein binding	IPI	21516116 25416956 29892012 31515488 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

dihydropyrimidinase activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dihydropyrimidinase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity

Displaying **all 3** entries
InterPro
Amidohydrolase-related
Metal-dependent hydrolase, composite domain superfamily
Metal-dependent hydrolase

Ortholog

Displaying entries **91 - 96** of 96 in total

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Species	Gene ID	Orthologous MAtrix
Rhinolophus ferrumequinum	117037539	RHIFE14623
Scophthalmus maximus	118284890	SCOMX09265
Balaenoptera musculus	118896737	BALMU12926
Anas platyrhynchos platyrhynchos	119713465	ANAPP27406
Panthera leo	122217495	PANLE26785
Ursus americanus	123777364	URSAM18092

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OrthoDB (Group)

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Acknowledgements