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dopamine receptor D5

Summary

Gene Symbol

DRD5

Organism

Homo sapiens (human)

External Links

NCBI Gene

1816

PubChem

1816

Alliance of Genome Resources

HGNC:3026

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
Dystonia
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P21918	D(5) dopamine receptor D1beta dopamine receptor Dopamine D5 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
synaptic transmission, dopaminergic	NAS	11036203
response to amphetamine	IEA
regulation of systemic arterial blood pressure by vasopressin	IEA
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IEA
intracellular calcium ion homeostasis	TAS	9457173

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, dopaminergic

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating dopamine receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

dopamine receptor signaling pathway

cellular metabolic process [inference]

reactive oxygen species metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus

reproductive process [inference]

reproductive behavior [inference]

mating behavior [inference]

female mating behavior [inference]

regulation of female receptivity

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

nervous system process [inference]

transmission of nerve impulse

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

nonassociative learning [inference]

sensitization

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by vasopressin

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

nonassociative learning [inference]

sensitization

reproductive behavior [inference]

mating behavior [inference]

female mating behavior [inference]

regulation of female receptivity

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus

response to organic cyclic compound [inference]

response to cocaine

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

response to oxygen-containing compound [inference]

response to cocaine

response to catecholamine [inference]

cellular response to catecholamine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus

response to salt [inference]

response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, dopaminergic

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating dopamine receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

dopamine receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by vasopressin

negative regulation of blood pressure

regulation of female receptivity

regulation of synaptic plasticity [inference]

long-term synaptic depression

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of NAD(P)H oxidase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

activation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

activation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity

activation of adenylate cyclase activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

activation of adenylate cyclase activity

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of NAD(P)H oxidase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

activation of adenylate cyclase activity

regulation of oxidoreductase activity [inference]

regulation of NAD(P)H oxidase activity [inference]

negative regulation of NAD(P)H oxidase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of NAD(P)H oxidase activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	NAS	1826762
plasma membrane	TAS	9457173
plasma membrane	IDA	10531415 11500503
plasma membrane	IBA
cilium	IDA	28154160

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

non-motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-motile cilium

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
dopamine neurotransmitter receptor activity, coupled via Gs	TAS	9457173
dopamine neurotransmitter receptor activity, coupled via Gs	IBA
G protein-coupled receptor activity	IBA
dopamine neurotransmitter receptor activity	IDA	1826762
protein binding	IPI	32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

dopamine binding

organic cyclic compound binding [inference]

catecholamine binding [inference]

dopamine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity

dopamine neurotransmitter receptor activity, coupled via Gs

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dopamine receptor

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources
DOID:529	blepharospasm	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	1812	FB:FBgn0011582
Xenopus tropicalis	1816	Xenbase:XB-GENE-992519
Drosophila melanogaster	13488	FB:FBgn0011582
Mus musculus	13492	Xenbase:XB-GENE-992519	MOUSE47239
Rattus norvegicus	25195	Xenbase:XB-GENE-992519	RATNO08457
Danio rerio	41726	ZFIN:ZDB-GENE-121214-145
Danio rerio	180714	ZFIN:ZDB-GENE-121214-145
Pan troglodytes	473340		PANTR33322
Canis lupus familiaris	488824		CANLF12223
Bos taurus	526221		BOVIN31848

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Acknowledgements