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Guidelines

MIRAGE

DOMON domain-containing protein;Tyramine beta-hydroxylase

Summary

Gene Symbol

tbh-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

181639

PubChem

181639

Alliance of Genome Resources

WB:WBGene00006541

Annotation

Keyword

Alternative splicing
Copper
Disulfide bond
Glycoprotein
Metal-binding
Monooxygenase
Neurotransmitter biosynthesis
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9XTQ6	Tyramine beta-monooxygenase
A0A0K3ATC0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
octopamine biosynthetic process	IMP	15848803
octopamine biosynthetic process	IBA
dopamine catabolic process	IBA
norepinephrine biosynthetic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

ethanolamine-containing compound metabolic process [inference]

octopamine metabolic process [inference]

octopamine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

octopamine metabolic process [inference]

octopamine biosynthetic process

alcohol biosynthetic process [inference]

octopamine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

ethanolamine-containing compound metabolic process [inference]

octopamine metabolic process [inference]

octopamine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

octopamine metabolic process [inference]

octopamine biosynthetic process

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
membrane	IEA
secretory granule membrane	IBA
synapse	IDA	15848803

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

cell junction [inference]

synapse

Displaying entries **6 - 9** of 9 in total

« First

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1

2
GO Term	Evidence Code	PMID
copper ion binding	IBA
copper ion binding	IEA
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity [inference]

monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

dopamine beta-monooxygenase activity

tyramine-beta hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

dopamine beta-monooxygenase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

copper ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DBH-like monooxygenase protein 1-like protein

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
catalytic activity
copper ion binding
dopamine beta-monooxygenase activity
dopamine catabolic process
metal ion binding
monooxygenase activity
norepinephrine biosynthetic process
octopamine biosynthetic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Displaying **all 10** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
Copper-dependent monooxygenases, DOMON domain
DOMON domain
Dopamine beta-hydroxylase-like
PHM/PNGase F domain superfamily
Tyramine beta-hydroxylase/Dopamine beta-hydroxylase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
synapse	PMID:15848803

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1621	Xenbase:XB-GENE-959495
Xenopus tropicalis	13166	Xenbase:XB-GENE-959495
Xenopus tropicalis	25699	Xenbase:XB-GENE-959495
Xenopus tropicalis	31718	Xenbase:XB-GENE-959495
Xenopus tropicalis	181639	Xenbase:XB-GENE-959495

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Acknowledgements

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025