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solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

Summary

Gene Symbol

Slc11a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18174

PubChem

18174

Alliance of Genome Resources

MGI:1345279

Annotation

Keyword

Alternative splicing
Cell membrane
Disease variant
Endosome
Glycoprotein
Golgi apparatus
Iron transport
Lysosome
Mitochondrion outer membrane
Phosphoprotein
Reference proteome
Symport
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P49282	Divalent cation transporter 1 Divalent metal transporter 1 Solute carrier family 11 member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
transition metal ion transport	ISO
porphyrin-containing compound metabolic process	IMP	4404581
porphyrin-containing compound biosynthetic process	IMP	658175
heme biosynthetic process	IMP	11739192
cobalt ion transport	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

pigment metabolic process [inference]

heme metabolic process [inference]

heme biosynthetic process

pigment biosynthetic process [inference]

heme biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

copper ion transmembrane transport

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

multicellular organismal-level iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport

cobalt ion transport

copper ion transport

copper ion transmembrane transport

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

iron ion transport

manganese ion transport

manganese ion transmembrane transport

cadmium ion transport [inference]

cadmium ion transmembrane transport

lead ion transport

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

copper ion transmembrane transport

plasma membrane copper ion transport [inference]

copper ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

copper ion import across plasma membrane

establishment of localization in cell

iron import into cell

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IEA
cytoplasm	ISO
mitochondrion	ISO
mitochondrial outer membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

paraferritin complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

organelle outer membrane [inference]

mitochondrial outer membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

extracellular vesicle

intracellular membrane-bounded organelle [inference]

vacuole

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

cluster of actin-based cell projections [inference]

brush border

Displaying entries **6 - 10** of 37 in total

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GO Term	Evidence Code	PMID
manganese ion transmembrane transporter activity	IEA
zinc ion transmembrane transporter activity	ISO
iron ion binding	ISO
copper ion binding	ISO
zinc ion binding	ISO