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desmocollin 3

Summary

Gene Symbol

DSC3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1825

PubChem

1825

Alliance of Genome Resources

HGNC:3037

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Direct protein sequencing
Glycoprotein
Hypotrichosis
Metal-binding
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14574	Cadherin family member 3 Desmocollin-4 HT-CP

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
in utero embryonic development	IEA
cell adhesion	TAS	7929347
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
protein stabilization	IDA	7983064
cell-cell adhesion	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological regulation [inference]

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cornified envelope	TAS
extracellular region	IEA
cytoplasm	IEA
plasma membrane	TAS
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cornified envelope

cell junction

anchoring junction [inference]

cell-cell junction

desmosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IBA
gamma-catenin binding	IPI	7983064

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

gamma-catenin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

desmocollin-1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
Gene Ontology
adherens junction organization
cadherin binding
calcium ion binding
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
sprouting angiogenesis

Displaying **all 8** entries
InterPro
Cadherin conserved site
Cadherin prodomain
Cadherin, Y-type LIR-motif
Cadherin-like superfamily
Cadherin-like
Cadherin
Catenin binding domain superfamily
Desmosomal cadherin

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1823	Xenbase:XB-GENE-976994
Xenopus tropicalis	1824	Xenbase:XB-GENE-976994
Xenopus tropicalis	1825	Xenbase:XB-GENE-976994
Xenopus tropicalis	13505	Xenbase:XB-GENE-976994
Xenopus tropicalis	13506	Xenbase:XB-GENE-976994
Mus musculus	13507	Xenbase:XB-GENE-976994	MOUSE23180
Rattus norvegicus	307563		RATNO13480
Pan troglodytes	455352		PANTR16072
Danio rerio	560091	Xenbase:XB-GENE-976994	DANRE18969
Macaca mulatta	712805		MACMU17461