GlyCosmos Portal

Submissions

DS cell adhesion molecule

Summary

Gene Symbol

DSCAM

Organism

Homo sapiens (human)

External Links

NCBI Gene

1826

PubChem

1826

Alliance of Genome Resources

HGNC:3039

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O60469	CHD2 Down syndrome cell adhesion molecule

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
synapse assembly	ISS
post-embryonic retina morphogenesis in camera-type eye	IEA
negative regulation of cell adhesion	ISS
retina layer formation	ISS
dendrite self-avoidance	IBA ISS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

cell recognition [inference]

neuron recognition [inference]

dendrite self-avoidance

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

camera-type eye photoreceptor cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic retina morphogenesis in camera-type eye

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

camera-type eye photoreceptor cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
membrane	TAS	9426258
neuronal cell body	IBA ISS
plasma membrane	IBA ISS TAS
extracellular region	IEA
dendrite	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane

cell junction [inference]

synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19196994 32296183 35914814
protein tyrosine kinase binding	IEA
netrin receptor binding	IPI	22685302
cell-cell adhesion mediator activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

netrin receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Down syndrome cell adhesion molecule-like protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cell-cell adhesion mediator activity

Displaying **all 8** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:14250	Down syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13508		MGI:1196281	MOUSE18568
Drosophila melanogaster	35652		FB:FBgn0033159
Drosophila melanogaster	38788		FB:FBgn0265296
Rattus norvegicus	171119		RGD:619992	RATNO04091
Danio rerio	386937		ZFIN:ZDB-GENE-031118-67
Danio rerio	568643		ZFIN:ZDB-GENE-050310-7
Macaca mulatta	722556			MACMU30544
Xenopus laevis	735085		Xenbase:XB-GENE-921696
Pan troglodytes	747803	9598_0:00522d		PANTR25709
Drosophila melanogaster	2769008		FB:FBgn0263219

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements