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dystrobrevin alpha

Summary

Gene Symbol

DTNA

Organism

Homo sapiens (human)

External Links

NCBI Gene

1837

PubChem

1837

Alliance of Genome Resources

HGNC:3057

Annotation

Keyword

3D-structure
Alternative splicing
Cardiomyopathy
Cell membrane
Coiled coil
Cytoplasm
Disease variant
Phosphoprotein
Reference proteome
Synapse
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Y4J8	Alpha-dystrobrevin Dystrophin-related protein 3
B7Z3X3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
striated muscle contraction	TAS	10767327
synaptic signaling	IBA
signal transduction	TAS	10767327
chemical synaptic transmission	TAS	8845841
neuromuscular synaptic transmission	TAS	9119373

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

signal transduction

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

regulation of cellular process [inference]

signal transduction

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GO Term	Evidence Code	PMID
cell junction	IDA
intermediate filament cytoskeleton	IDA
sarcolemma	IEA
protein-containing complex	IDA	18468998
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcolemma

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of cytoplasmic side of plasma membrane

cell junction

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10767429 11353857 19931615 21115837 33961781 35271311 9356463
zinc ion binding	IEA
PDZ domain binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

PDZ domain binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dystrobrevin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
metal ion binding
synaptic signaling
zinc ion binding

Displaying **all 5** entries
InterPro
EF-hand domain pair
EF-hand domain, type 1
EF-hand domain, type 2
Zinc finger, ZZ-type superfamily
Zinc finger, ZZ-type

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0060480	left ventricular noncompaction	Alliance of Genome Resources
DOID:11723	Duchenne muscular dystrophy	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13527		MGI:106039	MOUSE23314
Drosophila melanogaster	36362		FB:FBgn0033739
Caenorhabditis elegans	171715		WB:WBGene00001115
Rattus norvegicus	307548		RGD:1561985	RATNO13900
Xenopus laevis	373790		Xenbase:XB-GENE-6252681
Xenopus laevis	414490		Xenbase:XB-GENE-6252834
Pan troglodytes	455367	9598_0:0048e1		PANTR16121
Canis lupus familiaris	490488			CANLF17541
Bos taurus	541153			BOVIN19474
Macaca mulatta	707887			MACMU17721

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UniCarb-DR

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements