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procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide

Summary

Gene Symbol

P4ha1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18451

PubChem

18451

Alliance of Genome Resources

MGI:97463

Annotation

Keyword

Alternative splicing
Dioxygenase
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Proteomics identification
Reference proteome
Signal
TPR repeat
Vitamin C

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3UF16	Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
Q60715	Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
E9Q7B0	Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
Q3TTT2	Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IDA	7753822
collagen fibril organization	IMP	17135260
collagen fibril organization	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

heterocycle metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

primary metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

organic cyclic compound metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

heterocycle metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrion	IEA
endoplasmic reticulum	ISO
endoplasmic reticulum	IBA
endoplasmic reticulum lumen	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

procollagen-proline 4-dioxygenase complex

catalytic complex [inference]

oxidoreductase complex [inference]

procollagen-proline 4-dioxygenase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
procollagen-proline 4-dioxygenase activity	ISO
procollagen-proline 4-dioxygenase activity	IDA	7753822
procollagen-proline 4-dioxygenase activity	IMP	17135260
procollagen-proline 4-dioxygenase activity	IBA
iron ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

binding [inference]

protein binding [inference]

identical protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prolyl 4-hydroxylase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 4-dioxygenase activity

Displaying **all 6** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase alpha-subunit, N-terminal
Prolyl 4-hydroxylase, alpha subunit
Prolyl 4-hydroxylase
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying entries **11 - 20** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Macaca mulatta	707927	MACMU46205
Monodelphis domestica	100010507	MONDO02731
Sus scrofa	100037299	PIGXX07803
Equus caballus	100063760	HORSE18037
Ornithorhynchus anatinus	100077226	ORNAN17559
Pongo abelii	100172658	PONAB01267
Taeniopygia guttata	100228350	TAEGU26745
Oryctolagus cuniculus	100340270	RABIT06705
Callithrix jacchus	100393458	CALJA07519
Ailuropoda melanoleuca	100480425	AILME11609