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peroxiredoxin 1

Summary

Gene Symbol

Prdx1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18477

PubChem

18477

Alliance of Genome Resources

MGI:99523

Annotation

Keyword

Acetylation
Antioxidant
Cytoplasm
Direct protein sequencing
Disulfide bond
Isopeptide bond
Peroxidase
Phosphoprotein
Redox-active center
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P35700	Macrophage 23 kDa stress protein Osteoblast-specific factor 3 Thioredoxin peroxidase 2 Thioredoxin-dependent peroxide reductase 2 Thioredoxin-dependent peroxiredoxin 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
response to reactive oxygen species	IMP	12891360 16170382 16297875
response to oxidative stress	IDA	8360158
response to oxidative stress	IMP	15858817
response to oxidative stress	IBA
canonical NF-kappaB signal transduction	IMP	15858817

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

lymphocyte mediated immunity [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

myeloid cell homeostasis [inference]

erythrocyte homeostasis

immune response [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

leukocyte activation

lymphocyte activation [inference]

natural killer cell activation

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

removal of superoxide radicals

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cell activation [inference]

leukocyte activation

lymphocyte activation [inference]

natural killer cell activation

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

signal transduction [inference]

intracellular signal transduction [inference]

canonical NF-kappaB signal transduction

cell population proliferation [inference]

fibroblast proliferation

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

removal of superoxide radicals

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation

lymphocyte activation [inference]

natural killer cell activation

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis [inference]

erythrocyte homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis [inference]

erythrocyte homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to oxidative stress

response to reactive oxygen species

immune response [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to chemical [inference]

response to oxygen-containing compound [inference]

response to reactive oxygen species

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of non-canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of non-canonical NF-kappaB signal transduction

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

canonical NF-kappaB signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of non-canonical NF-kappaB signal transduction

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
euchromatin	ISO
nucleus	ISO
cytoplasm	ISO
mitochondrion	HDA	18614015
mitochondrial matrix	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin [inference]

euchromatin

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

microbody lumen [inference]

peroxisomal matrix

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
peroxidase activity	ISO
protein binding	IPI	21516123
thioredoxin peroxidase activity	ISO
thioredoxin peroxidase activity	IBA
thioredoxin peroxidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

peroxiredoxin activity

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

binding [inference]

protein binding

identical protein binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

peroxiredoxin activity

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peroxiredoxin

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
antioxidant activity
cellular oxidant detoxification
oxidoreductase activity
peroxiredoxin activity

Displaying **all 5** entries
InterPro
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Peroxiredoxin, AhpC-type
Peroxiredoxin, C-terminal
Thioredoxin domain
Thioredoxin-like superfamily

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5052	Xenbase:XB-GENE-481165	HUMAN49590
Xenopus tropicalis	7001	Xenbase:XB-GENE-945852
Saccharomyces cerevisiae S288C	11757	SGD:S000002861
Xenopus tropicalis	18477	Xenbase:XB-GENE-481165
Saccharomyces cerevisiae S288C	64371	SGD:S000002861
Rattus norvegicus	117254		RATNO32556
Bos taurus	281997		BOVIN27063
Pan troglodytes	456537		PANTR20946
Canis lupus familiaris	475375		CANLF04073
Ciona intestinalis	493870		CIOIN13580