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pregnancy-associated plasma protein A

Summary

Gene Symbol

Pappa

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18491

PubChem

18491

Alliance of Genome Resources

MGI:97479

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Secreted
Signal
Sushi
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8R4K8	Insulin-like growth factor-dependent IGF-binding protein 4 protease Pregnancy-associated plasma protein A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteolysis	IBA IEA
response to follicle-stimulating hormone	IEA
cell surface receptor signaling pathway	IBA
response to dexamethasone	IEA ISO
protein catabolic process	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multi-multicellular organism process [inference]

female pregnancy

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to gonadotropin [inference]

response to follicle-stimulating hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to gonadotropin [inference]

response to follicle-stimulating hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to ketone [inference]

response to dexamethasone

response to oxygen-containing compound [inference]

response to ketone [inference]

response to dexamethasone

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular space	HDA IBA ISO	24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
metalloendopeptidase activity	IBA ISO
endopeptidase activity	IDA	11985604
metallopeptidase activity	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

pappalysin-1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism

Displaying **all 4** entries
Gene Ontology
cell surface receptor signaling pathway
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 2** entries
InterPro
Notch domain
Pappalysin-1/2

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3407	carotid artery disease	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:90	degenerative disc disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **109** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5069		HGNC:8602	HUMAN98178
Bos taurus	282647			BOVIN35196
Rattus norvegicus	313262	10116_1:002186	RGD:1307742	RATNO33990
Ovis aries	443157			SHEEP08674
Pan troglodytes	464690			PANTR44683
Canis lupus familiaris	481692			CANLF02479
Macaca mulatta	706783			MACMU13317
Monodelphis domestica	100014138			MONDO01673
Equus caballus	100033920			HORSE24455
Ornithorhynchus anatinus	100077262			ORNAN20682

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements