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proprotein convertase subtilisin/kexin type 2

Summary

Gene Symbol

Pcsk2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18549

PubChem

18549

Alliance of Genome Resources

MGI:97512

Annotation

Keyword

Cleavage on pair of basic residues
Coiled coil
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P21661	KEX2-like endoprotease 2 Prohormone convertase 2 Proprotein convertase 2
Q547J8

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
insulin processing	IMP ISO	9452465
proteolysis	IMP ISO	12859669
protein autoprocessing	IDA	16893422
peptide hormone processing	IBA IDA IMP ISO	12859669 9242664
nervous system development	IEP	16893422

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

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GO Term	Evidence Code	PMID
secretory granule lumen	TAS
membrane	IBA IEA ISO
secretory granule	IDA ISO	9452465
perikaryon	IEA ISO
neuronal cell body	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

cell body [inference]

neuronal cell body

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endopeptidase activity	IDA	9242664
serine-type endopeptidase activity	IBA IDA IMP ISO TAS	8262946 9452465

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

neuroendocrine convertase 2

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

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InterPro
Peptidase S8/S53 domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **109** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Felis catus	101098130		FELCA07497
Gorilla gorilla gorilla	101144581		GORGO22449
Tursiops truncatus	101327547		TURTR14038
Octodon degus	101566975	10160_0:0026bd	OCTDE14299
Jaculus jaculus	101596368	51337_0:00289d	JACJA20647
Heterocephalus glaber	101710029	10181_0:000c5f	HETGA00677
Melopsittacus undulatus	101871682		MELUD10892
Ictidomys tridecemlineatus	101970522	43179_0:004388	ICTTR08165
Microtus ochrogaster	101993284	79684_0:003b33
Chinchilla lanigera	102008940	34839_0:000fd3	CHILA04959

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements