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proprotein convertase subtilisin/kexin type 5

Summary

Gene Symbol

Pcsk5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18552

PubChem

18552

Alliance of Genome Resources

MGI:97515

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Direct protein sequencing
Glycoprotein
Pregnancy
Reference proteome
Repeat
Secreted
Serine protease
Signal
Transmembrane helix
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q91VK0
Q04592	Proprotein convertase 5 Proprotein convertase 6 Subtilisin-like proprotein convertase 6 Subtilisin/kexin-like protease PC5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
kidney development	ISO
kidney development	IMP	18519639
cardiac septum development	IMP	25807483
signal peptide processing	ISO
determination of left/right symmetry	IMP	25807483

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

viral process [inference]

viral life cycle

reproductive process [inference]

embryo implantation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

limb morphogenesis

anatomical structure development [inference]

blood vessel development [inference]

coronary vasculature development

cardiac septum development

tube development [inference]

respiratory tube development

digestive tract development [inference]

embryonic digestive tract development

animal organ development [inference]

embryonic organ development [inference]

embryonic digestive tract development

system development [inference]

skeletal system development [inference]

embryonic skeletal system development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of integrin activation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of integrin activation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

regulation of smooth muscle cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of integrin activation

regulation of integrin activation [inference]

positive regulation of integrin activation

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of integrin activation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of integrin activation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of integrin activation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of integrin activation

regulation of integrin activation [inference]

positive regulation of integrin activation

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of integrin activation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IBA
extracellular space	IDA	8940009
extracellular space	HDA	24006456
endoplasmic reticulum lumen	TAS
Golgi apparatus	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

Golgi cisterna [inference]

Golgi medial cisterna

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite [inference]

proximal dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISO
endopeptidase activity	IDA	18519639 9242664
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IDA	8468318
serine-type endopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

amide binding [inference]

peptide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 8** entries
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:14679	VACTERL association	Alliance of Genome Resources
DOID:9562	primary ciliary dyskinesia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 55 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	5045	SGD:S000005182
Saccharomyces cerevisiae S288C	5046	SGD:S000005182
Saccharomyces cerevisiae S288C	5122	SGD:S000005182
Homo sapiens	5125	Xenbase:XB-GENE-959596	HUMAN97316
Saccharomyces cerevisiae S288C	9159	SGD:S000005182
Saccharomyces cerevisiae S288C	18548	SGD:S000005182
Saccharomyces cerevisiae S288C	18550	SGD:S000005182
Saccharomyces cerevisiae S288C	18551	SGD:S000005182
Xenopus tropicalis	18552	Xenbase:XB-GENE-959596
Saccharomyces cerevisiae S288C	18553	SGD:S000005182

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements