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programmed cell death 1

Summary

Gene Symbol

Pdcd1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18566

PubChem

18566

Alliance of Genome Resources

MGI:104879

Annotation

Keyword

3D-structure
Adaptive immunity
Apoptosis
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Isopeptide bond
Phosphoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q02242
Q544F3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
B cell apoptotic process	IMP	23636058
adaptive immune response	IEA
negative regulation of tolerance induction	IMP	23636058
negative regulation of T cell mediated immune response to tumor cell	ISO
negative regulation of T cell mediated immune response to tumor cell	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

B cell apoptotic process

T cell apoptotic process [inference]

regulatory T cell apoptotic process

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of tolerance induction [inference]

negative regulation of tolerance induction

negative regulation of immune system process [inference]

negative regulation of tolerance induction

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of tolerance induction

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of developmental process [inference]

negative regulation of tolerance induction

negative regulation of multicellular organismal process [inference]

negative regulation of tolerance induction

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of response to tumor cell [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of tolerance induction

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of lymphocyte apoptotic process [inference]

regulation of B cell apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

regulation of T cell apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of tolerance induction

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IDA	15568026 23583643
external side of plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15568026 18641123 21884581 23417675
signaling receptor activity	ISS
signaling receptor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Programmed cell death protein 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
negative regulation of immune response
positive regulation of T cell apoptotic process
regulation of immune response

Displaying **all 6** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Programmed cell death protein 1

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5133	HGNC:8760	HUMAN68124
Homo sapiens	18566	HGNC:8760
Rattus norvegicus	301626		RATNO42979
Canis lupus familiaris	486213		CANLF10191
Bos taurus	613842		BOVIN27536
Pan troglodytes	748796		PANTR30273
Equus caballus	100067948		HORSE37008
Felis catus	100135770		FELCA19992
Macaca mulatta	100135775		MACMU05848
Oryctolagus cuniculus	100343779		RABIT18030

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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OrthoDB (Group)

International Collaboration

Acknowledgements