GlyCosmos Portal

Submissions

pyruvate dehydrogenase kinase, isoenzyme 2

Summary

Gene Symbol

Pdk2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18604

PubChem

18604

Alliance of Genome Resources

MGI:1343087

Annotation

Keyword

ATP-binding
Kinase
Mitochondrion
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JK42	Pyruvate dehydrogenase kinase isoform 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
regulation of gluconeogenesis	IMP	22360721
regulation of pH	IMP	22360721
insulin receptor signaling pathway	IMP	22360721
regulation of acetyl-CoA biosynthetic process from pyruvate	IMP	22360721
regulation of acetyl-CoA biosynthetic process from pyruvate	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of pH

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of amide metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of glucose metabolic process

regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
mitochondrion	ISO
mitochondrion	IDA	21190881
mitochondrion	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex [inference]

pyruvate dehydrogenase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
protein serine/threonine kinase activity	ISO
pyruvate dehydrogenase (acetyl-transferring) kinase activity	ISO
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IMP	22360721
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA
protein binding	IPI	15102471

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pyruvate dehydrogenase kinase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
pyruvate dehydrogenase (acetyl-transferring) kinase activity
regulation of glucose metabolic process
transferase activity

Displaying **all 6** entries
InterPro
Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
Histidine kinase domain
Histidine kinase/HSP90-like ATPase superfamily
Histidine kinase/HSP90-like ATPase
PDK/BCKDK protein kinase

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements