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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
ATP-binding cassette, sub-family B member 4
Summary
- Gene Symbol
-
- Abcb4
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- ATP-binding
- Cell membrane
- Cytoplasm
- Cytoplasmic vesicle
- Glycoprotein
- Lipid transport
- Phosphoprotein
- Reference proteome
- Repeat
- Translocase
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P21440 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| xenobiotic transmembrane transport | ||
| positive regulation of phospholipid translocation | ||
| bile acid secretion | ||
| response to fenofibrate | ||
| phospholipid translocation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane | ||
| intercellular canaliculus | ||
| focal adhesion | ||
| apical plasma membrane | ||
| clathrin-coated vesicle |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| ABC-type transporter activity | ||
| phosphatidylcholine floppase activity | ||
| ATP hydrolysis activity | ||
| ATPase-coupled transmembrane transporter activity | ||
| ATP binding |
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- phosphatidylcholine translocator ABCB4
- Functional Category
-
- E: Amino acid transport and metabolism
- P: Inorganic ion transport and metabolism
- V: Defense mechanisms
| Gene Ontology |
|---|
| ABC-type oligopeptide transporter activity |
| ABC-type transporter activity |
| ATP binding |
| nucleotide binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060643 | primary sclerosing cholangitis | |
| DOID:0070223 | progressive familial intrahepatic cholestasis 3 | |
| DOID:0070229 | intrahepatic cholestasis of pregnancy 3 | |
| DOID:12236 | primary biliary cholangitis | |
| DOID:13580 | cholestasis | |
| DOID:1485 | cystic fibrosis | |
| DOID:1852 | intrahepatic cholestasis | |
| DOID:1949 | cholecystitis | |
| DOID:5082 | liver cirrhosis | |
| DOID:684 | hepatocellular carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 5244 | HGNC:45 | HUMAN89693 | ||
| 24891 | 10116_1:001cbe | RGD:620248 | RATNO30604 | |
| 36428 | FB:FBgn0004512 | |||
| 36582 | FB:FBgn0010241 | |||
| 38725 | FB:FBgn0035695 | |||
| 38726 | FB:FBgn0004513 | |||
| 172262 | WB:WBGene00003996 | |||
| 178215 | WB:WBGene00003995 | |||
| 180165 | WB:WBGene00004003 | |||
| 181326 | WB:WBGene00003997 |
