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paired Ig-like receptor B

Summary

Gene Symbol

Pirb

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18733

PubChem

18733

Alliance of Genome Resources

MGI:894311

Annotation

Keyword

Adaptive immunity
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P97484	Cell-surface glycoprotein p91 Paired immunoglobulin-like receptor B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
B cell homeostasis	IMP	12021780
immune response-regulating signaling pathway	IBA
learning or memory	IGI	24052308
cytokine-mediated signaling pathway	IMP	12021780
cytokine-mediated signaling pathway	IBA

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation

signal transduction [inference]

immune response-regulating signaling pathway

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation

mononuclear cell differentiation [inference]

dendritic cell differentiation [inference]

myeloid dendritic cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation

mononuclear cell differentiation [inference]

dendritic cell differentiation [inference]

myeloid dendritic cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

negative regulation of protein metabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

negative regulation of protein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

negative regulation of protein metabolic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

regulation of long-term synaptic depression [inference]

positive regulation of long-term synaptic depression

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of long-term synaptic depression

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

regulation of response to stimulus [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

regulation of long-term synaptic depression [inference]

positive regulation of long-term synaptic depression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of protein dephosphorylation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

regulation of long-term synaptic depression [inference]

positive regulation of long-term synaptic depression

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular space	ISO
cytoplasm	ISO
plasma membrane	IBA
plasma membrane	IEA
external side of plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	ISO
amyloid-beta binding	IDA	24052308
amyloid-beta binding	IMP	24052308
protein binding	IPI	22660330 24052308
protein phosphatase 1 binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

MHC protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 1 binding

protein domain specific binding [inference]

SH2 domain binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding

MHC protein complex binding [inference]

MHC class Ib protein complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

MHC class I receptor activity

inhibitory MHC class I receptor activity

MHC class Ib receptor activity

immune receptor activity [inference]

MHC class I receptor activity

inhibitory MHC class I receptor activity

MHC class Ib receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Immunoglobulin

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
cell surface receptor signaling pathway

Displaying **all 3** entries
InterPro
Immunoglobulin-like domain superfamily
Immunoglobulin-like fold
Immunoglobulin

Ortholog

Displaying entries **1 - 10** of 13 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10288	HGNC:6606
Homo sapiens	10859	HGNC:6605
Homo sapiens	10990	HGNC:6609
Rattus norvegicus	11024	RGD:1589827
Homo sapiens	11026	HGNC:6604
Rattus norvegicus	11027	RGD:1589827
Homo sapiens	18733	HGNC:6609
Rattus norvegicus	23547	RGD:1307219
Homo sapiens	65146	HGNC:6609
Rattus norvegicus	361493		RATNO19910

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements