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phospholipase A2 receptor 1

Summary

Gene Symbol

Pla2r1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18779

PubChem

18779

Alliance of Genome Resources

MGI:102468

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Endocytosis
Glycoprotein
Lectin
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q62028	180 kDa secretory phospholipase A2 receptor M-type receptor
Q8CB47

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
positive regulation of cytokine production	ISS
positive regulation of cytokine production	ISO
receptor-mediated endocytosis	ISO
receptor-mediated endocytosis	IDA	7925459
positive regulation of DNA damage response, signal transduction by p53 class mediator	ISS

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process

cellular senescence [inference]

stress-induced premature senescence [inference]

oxidative stress-induced premature senescence

replicative senescence

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular metabolic process [inference]

reactive oxygen species metabolic process

cellular senescence [inference]

stress-induced premature senescence [inference]

oxidative stress-induced premature senescence

replicative senescence

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonic acid secretion [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonic acid secretion [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of secretion [inference]

regulation of icosanoid secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonic acid secretion [inference]

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of organic acid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonic acid secretion [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of organic acid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

regulation of epithelial cell apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

regulation of podocyte apoptotic process [inference]

positive regulation of podocyte apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

regulation of cellular response to stress [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

regulation of lipase activity [inference]

regulation of phospholipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

regulation of phospholipase A2 activity [inference]

negative regulation of phospholipase A2 activity

negative regulation of lipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA	11830583
extracellular region	IEA
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
carbohydrate binding	IEA
signaling receptor activity	ISS	8550569
signaling receptor activity	ISO
signaling receptor activity	IBA
phospholipase binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

phospholipase binding

carbohydrate binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

secretory phospholipase A2 receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
InterPro
C-type lectin fold
C-type lectin-like/link domain superfamily
C-type lectin-like
Fibronectin type II domain superfamily
Fibronectin type II domain
Kringle-like fold
Ricin B, lectin domain
Ricin B-like lectins

Ortholog

Displaying entries **11 - 20** of 89 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Macaca mulatta	700191		MACMU07156
Pan troglodytes	739140		PANTR28942
Oryctolagus cuniculus	100009180		RABIT11709
Monodelphis domestica	100022002		MONDO22778
Equus caballus	100060317		HORSE13715
Ornithorhynchus anatinus	100081912		ORNAN27289
Pongo abelii	100173143		PONAB24752
Callithrix jacchus	100401998		CALJA37667
Ailuropoda melanoleuca	100483969		AILME03340
Caenorhabditis elegans	100526664	WB:WBGene00015050

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements