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plectin

Summary

Gene Symbol

Plec

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18810

PubChem

18810

Alliance of Genome Resources

MGI:1277961

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Cell junction
Cell projection
Coiled coil
Cytoskeleton
Direct protein sequencing
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain

Proteins

Displaying **all 8** entries
UniProt	Protein Name
Q6S387	Plectin-1
Q6S388	Plectin-1
Q6S385	Plectin-1
Q9QXS1	Plectin-1 Plectin-6
Q6S392	Plectin-1
E9Q3W4	Plectin-1
Q6S390	Plectin-1
Q6S393	Plectin-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 46 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IMP	9808630
leukocyte migration involved in immune response	IMP	16344482
keratinocyte development	IMP	17606998
negative regulation of protein kinase activity	IMP	12200133
nucleus organization	IMP	26487297

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte migration involved in immune response

leukocyte migration [inference]

leukocyte migration involved in immune response

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

T cell migration [inference]

T cell chemotaxis

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

peripheral nervous system axon ensheathment [inference]

myelination in peripheral nervous system

myelination [inference]

myelination in peripheral nervous system

cell cycle process [inference]

actomyosin contractile ring assembly actin filament organization

actin filament-based process [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

myofibril assembly [inference]

skeletal myofibril assembly

sarcomere organization

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization

intermediate filament organization

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

myoblast differentiation

cell development [inference]

epithelial cell development [inference]

keratinocyte development

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cell motility

cell migration [inference]

ameboidal-type cell migration [inference]

fibroblast migration

leukocyte migration [inference]

leukocyte migration involved in immune response

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

T cell migration [inference]

T cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular response to stimulus

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to hydrostatic pressure

cellular response to fluid shear stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to hydrostatic pressure

cellular response to acid chemical [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to oxygen-containing compound [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to salt [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

myofibril assembly [inference]

skeletal myofibril assembly

sarcomere organization

intermediate filament cytoskeleton organization

intermediate filament organization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly [inference]

skeletal myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly [inference]

skeletal myofibril assembly

cell junction assembly [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly [inference]

skeletal myofibril assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

cell-cell junction organization [inference]

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

protein-containing complex organization

membrane organization [inference]

plasma membrane organization [inference]

myelin maintenance [inference]

peripheral nervous system myelin maintenance

supramolecular fiber organization [inference]

actin filament organization

actomyosin contractile ring assembly actin filament organization

myofibril assembly [inference]

skeletal myofibril assembly

intermediate filament organization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability

nervous system process [inference]

transmission of nerve impulse

multicellular organism growth

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly [inference]

skeletal myofibril assembly

anatomical structure development [inference]

tissue development [inference]

epidermis development [inference]

skin epidermis development [inference]

establishment of skin barrier

epithelium development [inference]

skin epidermis development [inference]

establishment of skin barrier

muscle tissue development [inference]

skeletal muscle tissue development

cell development [inference]

epithelial cell development [inference]

keratinocyte development

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

animal organ development [inference]

skin development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

myoblast differentiation

cell development [inference]

epithelial cell development [inference]

keratinocyte development

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

growth [inference]

developmental growth [inference]

multicellular organism growth

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to hydrostatic pressure

cellular response to fluid shear stress

response to fluid shear stress [inference]

cellular response to fluid shear stress

response to hydrostatic pressure [inference]

cellular response to hydrostatic pressure

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to water [inference]

response to hydrostatic pressure [inference]

cellular response to hydrostatic pressure

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

response to chemical [inference]

response to acid chemical [inference]

response to water [inference]

response to hydrostatic pressure [inference]

cellular response to hydrostatic pressure

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to acid chemical [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

response to nutrient

response to organic substance [inference]

response to water [inference]

response to hydrostatic pressure [inference]

cellular response to hydrostatic pressure

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

response to inorganic substance [inference]

response to water [inference]

response to hydrostatic pressure [inference]

cellular response to hydrostatic pressure

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

response to food

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to hydrostatic pressure

cellular response to acid chemical [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to oxygen-containing compound [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to salt [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

response to oxygen-containing compound [inference]

response to water [inference]

response to hydrostatic pressure [inference]

cellular response to hydrostatic pressure

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to oxygen-containing compound [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

response to salt [inference]

response to water [inference]

response to hydrostatic pressure [inference]

cellular response to hydrostatic pressure

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to salt [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to stimulus

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to hydrostatic pressure

cellular response to fluid shear stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to hydrostatic pressure

cellular response to acid chemical [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to oxygen-containing compound [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to salt [inference]

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to water stimulus [inference]

cellular response to hydrostatic pressure

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of biological quality [inference]

regulation of vascular permeability

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity

regulation of ATP citrate synthase activity

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GO Term	Evidence Code	PMID
podosome	IDA	23525008
cytoplasm	IDA	23836526
cytoplasm	IBA
mitochondrial outer membrane	IMP	18541706
cytosol	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

sarcoplasm

cytosol

membrane [inference]

plasma membrane [inference]

sarcolemma

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

plasma membrane region [inference]

Z disc

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

myelin sheath

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton

intermediate filament cytoskeleton

contractile fiber

myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton

intermediate filament cytoskeleton

contractile fiber

myofibril

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber

myofibril

polymeric cytoskeletal fiber [inference]

intermediate filament

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GO Term	Evidence Code	PMID
dystroglycan binding	IDA	23836526
actin binding	IDA	10556294
structural constituent of cytoskeleton	ISO
structural constituent of cytoskeleton	IBA
protein binding	IPI	12200133 15128297 16608880 17389230 18827015 19932097 24940650 25703379 29128334

GO Hierarchy

molecular function

structural molecule activity [inference]

binding [inference]

protein binding

dystroglycan binding

cytoskeletal protein binding

actin binding

actin filament binding

ankyrin binding

identical protein binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Plectin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ankyrin binding
cadherin binding
hemidesmosome assembly
intermediate filament cytoskeleton organization
structural constituent of cytoskeleton
structural constituent of muscle
wound healing

Displaying **all 4** entries
InterPro
Desmoplakin, spectrin-like domain
Plakin repeat superfamily
Plakin
Plectin repeat

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060736	epidermolysis bullosa simplex Ogna type	Alliance of Genome Resources
DOID:0090017	epidermolysis bullosa simplex with muscular dystrophy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements