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plexin A1

Summary

Gene Symbol

Plxna1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18844

PubChem

18844

Alliance of Genome Resources

MGI:107685

Annotation

Keyword

3D-structure
Cell membrane
Coiled coil
Disulfide bond
Glycoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P70206

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA	16715077
synapse assembly	IBA
regulation of smooth muscle cell migration	IMP	14977921
olfactory nerve formation	IGI	31690636
gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IGI	31690636

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

cell motility [inference]

cell migration [inference]

neuron migration [inference]

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

hypothalamus cell migration [inference]

hypothalamic tangential migration using cell-axon interactions [inference]

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in salivary gland branching

anatomical structure formation involved in morphogenesis [inference]

cranial nerve formation [inference]

olfactory nerve formation

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of smooth muscle cell migration

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

regulation of cell motility [inference]

regulation of cell migration

regulation of smooth muscle cell migration

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
semaphorin receptor complex	IDA	16715077
semaphorin receptor complex	IBA
nucleoplasm	ISO
nucleoplasm	IEA
cytosol	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

semaphorin receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse

glutamatergic synapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10520994 14977921 16715077 18287072 22522930
semaphorin receptor activity	IDA	16715077
semaphorin receptor activity	IBA
semaphorin receptor activity	IPI	15239958 17145500

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

semaphorin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

plexin A

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
negative regulation of cell adhesion
positive regulation of axonogenesis
regulation of cell migration
semaphorin receptor activity
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway

Displaying entries **1 - 10** of 13 in total

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InterPro
IPT domain
Immunoglobulin E-set
Immunoglobulin-like fold
PSI domain
Plexin family
Plexin repeat
Plexin, TIG domain 1
Plexin, cytoplasmic RasGAP domain
Plexin, cytoplasmic RhoGTPase-binding domain
Rho GTPase activation protein

Ortholog

Displaying entries **1 - 10** of **110** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5361	Xenbase:XB-GENE-5819524	HUMAN72071
Drosophila melanogaster	5362	FB:FBgn0025741
Xenopus tropicalis	18844	Xenbase:XB-GENE-5819524
Drosophila melanogaster	18845	FB:FBgn0025741
Drosophila melanogaster	18846	FB:FBgn0025741
Xenopus tropicalis	43832	Xenbase:XB-GENE-5819524
Drosophila melanogaster	55558	FB:FBgn0025741
Drosophila melanogaster	91584	FB:FBgn0025741
Drosophila melanogaster	243743	FB:FBgn0025741
Xenopus tropicalis	246019	Xenbase:XB-GENE-5819524