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endothelin converting enzyme 1

Summary

Gene Symbol

ECE1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1889

PubChem

1889

Alliance of Genome Resources

HGNC:3146

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Hirschsprung disease
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P42892

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 20 in total

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GO Term	Evidence Code	PMID
ear development	IMP	9915973
pharyngeal system development	IEA
axonogenesis involved in innervation	IEA
sympathetic neuron axon guidance	IEA
semaphorin-plexin signaling pathway involved in axon guidance	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

endothelin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

endothelin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

catabolic process [inference]

hormone catabolic process

calcitonin catabolic process

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

hormone metabolic process [inference]

peptide hormone processing

endothelin maturation

hormone catabolic process

calcitonin catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

endothelin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway [inference]

semaphorin-plexin signaling pathway involved in neuron projection guidance [inference]

semaphorin-plexin signaling pathway involved in axon guidance

G protein-coupled receptor signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

sympathetic neuron axon guidance

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by endothelin

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

embryonic morphogenesis [inference]

embryonic digit morphogenesis

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

embryonic heart tube development

tube development [inference]

embryonic heart tube development

animal organ development [inference]

sensory organ development [inference]

ear development

heart development

system development [inference]

pharyngeal system development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of signaling [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of signaling [inference]

positive regulation of receptor recycling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway [inference]

semaphorin-plexin signaling pathway involved in neuron projection guidance [inference]

semaphorin-plexin signaling pathway involved in axon guidance

G protein-coupled receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by endothelin

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

endothelin maturation

hormone catabolic process

calcitonin catabolic process

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA
external side of plasma membrane	IDA	9449382 9710124
endosome membrane	TAS	18039931
membrane	IDA	7805846
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	IDA	18039931 7805846
metalloendopeptidase activity	ISS	8062389
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IBA
protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endothelin-converting enzyme

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M13, C-terminal domain
Peptidase M13, N-terminal domain
Peptidase M13, domain 2
Peptidase M13

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 80 in total

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Species	Gene ID	Orthologous MAtrix
Ictidomys tridecemlineatus	101976680	ICTTR08806
Chinchilla lanigera	102028052	CHILA13300
Capra hircus	102189723	CAPHI19899
Latimeria chalumnae	102351994	LATCH18582
Myotis lucifugus	102435850	MYOLU08171
Pelodiscus sinensis	102447588	PELSI01707
Callorhinchus milii	103181382	CALMI22619
Chlorocebus sabaeus	103225440	CHLSB09279
Ursus maritimus	103666584	URSMA06079
Nannospalax galili	103738572	NANGA21919

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OrthoDB (Group)

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Acknowledgements