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periplakin

Summary

Gene Symbol

Ppl

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19041

PubChem

19041

Alliance of Genome Resources

MGI:1194898

Annotation

Keyword

Cell junction
Cell membrane
Coiled coil
Cytoskeleton
Keratinization
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9R269
G5E898
Q3UQD7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
regulation of antibacterial peptide production	IGI	27427436
keratinization	IEA
wound healing	IBA
intermediate filament cytoskeleton organization	IBA
intermediate filament cytoskeleton organization	IEA

GO Hierarchy

biological process

cellular process [inference]

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization

multicellular organismal process [inference]

keratinization

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of antimicrobial peptide production [inference]

regulation of antibacterial peptide production

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cornified envelope	IDA	26644517
cytoplasm	IDA	19029034
cytoplasm	IBA
cytoskeleton	IEA
intermediate filament	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

cornified envelope

extrinsic component of membrane [inference]

extrinsic component of plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying **all 2** entries
GO Term	Evidence Code	PMID
structural molecule activity	IBA
protein binding	IPI	12244133 19029034

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

periplakin

Functional Category

H: Coenzyme transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cadherin binding
intermediate filament cytoskeleton organization
structural molecule activity
wound healing

Displaying **all 5** entries
InterPro
Desmoplakin, SH3 domain
Plakin repeat superfamily
Plakin
Plectin repeat
Spectrin/alpha-actinin

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5493	Xenbase:XB-GENE-1008954	HUMAN26447
Xenopus tropicalis	19041	Xenbase:XB-GENE-1008954
Rattus norvegicus	302934		RATNO00312
Danio rerio	449936		DANRE30458
Pan troglodytes	453893		PANTR11677
Canis lupus familiaris	490021		CANLF16599
Macaca mulatta	710266		MACMU27100
Monodelphis domestica	100026830		MONDO29501
Equus caballus	100069951		HORSE06533
Ornithorhynchus anatinus	100080483		ORNAN15065