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Guidelines

MIRAGE

palmitoyl-protein thioesterase 1

Summary

Gene Symbol

Ppt1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19063

PubChem

19063

Alliance of Genome Resources

MGI:1298204

Annotation

Keyword

Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3U6W3	Palmitoyl-protein hydrolase 1
O88531	Palmitoyl-protein hydrolase 1
Q3TEL0	Palmitoyl-protein hydrolase 1
Q3U6J9	Palmitoyl-protein hydrolase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
protein depalmitoylation	ISS
protein depalmitoylation	ISO
protein depalmitoylation	IMP	11717424 16242638
endocytosis	IBA
receptor-mediated endocytosis	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

protein metabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein metabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

macromolecule modification [inference]

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule depalmitoylation [inference]

protein depalmitoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

organic substance catabolic process [inference]

macromolecule catabolic process

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular process [inference]

vesicle-mediated transport [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

membrane organization [inference]

membrane raft organization

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

grooming behavior

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

system development [inference]

nervous system development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

vesicle-mediated transport [inference]

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

import into cell [inference]

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

neurotransmitter secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cell growth

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cell growth

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

regulation of biological quality [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of lipase activity [inference]

regulation of phospholipase activity [inference]

regulation of phospholipase A2 activity

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular region	IBA
extracellular space	IDA	9685319
nucleus	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosolic region [inference]

presynaptic cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

membrane microdomain [inference]

membrane raft

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
protein binding	IPI	19941651
palmitoyl-(protein) hydrolase activity	ISS
palmitoyl-(protein) hydrolase activity	ISO
palmitoyl-(protein) hydrolase activity	IDA	12483688
palmitoyl-(protein) hydrolase activity	IMP	11717424 16242638

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

CoA hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

long-chain acyl-CoA hydrolase activity

palmitoyl hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

catalytic activity, acting on a protein [inference]

palmitoyl-(protein) hydrolase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

ion binding [inference]

anion binding [inference]

lysophosphatidic acid binding

carbohydrate derivative binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

palmitoyl protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
hydrolase activity
macromolecule depalmitoylation
nervous system development
palmitoyl hydrolase activity
palmitoyl-(protein) hydrolase activity
receptor-mediated endocytosis

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Palmitoyl protein thioesterase

Rhea

H₂O

H⁺ + hexadecanoate

Enzyme

3.1.2.22

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110721	neuronal ceroid lipofuscinosis 1	Alliance of Genome Resources
DOID:0110731	neuronal ceroid lipofuscinosis 3	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003778
Gene Name: palmitoyl-protein thioesterase 1

Ortholog

Displaying entries **11 - 20** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Monodelphis domestica	100032080		MONDO22911
Ornithorhynchus anatinus	100077897		ORNAN08375
Pongo abelii	100174770		PONAB17049
Ciona intestinalis	100177362		CIOIN14534
Taeniopygia guttata	100190233		TAEGU13513
Oryctolagus cuniculus	100339827		RABIT04056
Callithrix jacchus	100403808		CALJA40070
Ailuropoda melanoleuca	100475095		AILME04237
Sus scrofa	100517533		PIGXX29701
Anolis carolinensis	100563048		ANOCA13148

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Last updated: December 8, 2025