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Guidelines

MIRAGE

proteinase 3

Summary

Gene Symbol

Prtn3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19152

PubChem

19152

Alliance of Genome Resources

MGI:893580

Annotation

Keyword

Cell membrane
Collagen degradation
Disulfide bond
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0R4IZY6
Q61096	Proteinase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
proteolysis	ISO
proteolysis	IBA
proteolysis	IEA
membrane protein ectodomain proteolysis	ISO
collagen catabolic process	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

cellular extravasation [inference]

neutrophil extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration [inference]

neutrophil extravasation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

mature conventional dendritic cell differentiation

mononuclear cell differentiation [inference]

dendritic cell differentiation [inference]

mature conventional dendritic cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

mature conventional dendritic cell differentiation

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

cellular extravasation [inference]

neutrophil extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration [inference]

neutrophil extravasation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell junction maintenance [inference]

cell-cell junction maintenance

cell-cell junction organization [inference]

cell-cell junction maintenance

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

mature conventional dendritic cell differentiation

mononuclear cell differentiation [inference]

dendritic cell differentiation [inference]

mature conventional dendritic cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

mature conventional dendritic cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of phagocytosis [inference]

negative regulation of phagocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of phagocytosis [inference]

negative regulation of phagocytosis

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of phagocytosis

regulation of phagocytosis [inference]

negative regulation of phagocytosis

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	IBA
lysosome	IEA
cytosol	ISO
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

plasma membrane raft

membrane microdomain [inference]

plasma membrane raft

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IBA
serine-type endopeptidase activity	IEA
signaling receptor binding	ISO
protein binding	IPI	25331958

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

neutrophil elastase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
acute inflammatory response to antigenic stimulus
hydrolase activity
phagocytosis
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **1 - 10** of 27 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1991	Xenbase:XB-GENE-5805214
Homo sapiens	5657	Xenbase:XB-GENE-5805214	HUMAN39246
Xenopus tropicalis	9757	Xenbase:XB-GENE-5805214
Xenopus tropicalis	19152	Xenbase:XB-GENE-5805214
Xenopus tropicalis	41737	Xenbase:XB-GENE-5805214
Xenopus tropicalis	50701	Xenbase:XB-GENE-5805214
Xenopus tropicalis	75410	Xenbase:XB-GENE-5805214
Pan troglodytes	749895		PANTR16591
Monodelphis domestica	100030473		MONDO01070
Bos taurus	100298591		BOVIN33356

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Last updated: April 7, 2025