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eukaryotic translation elongation factor 1 alpha 2

Summary

Gene Symbol

EEF1A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1917

PubChem

1917

Alliance of Genome Resources

HGNC:3192

Annotation

Keyword

3D-structure
Acetylation
Autism spectrum disorder
Disease variant
Elongation factor
Epilepsy
GTP-binding
Intellectual disability
Methylation
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q05639	Eukaryotic elongation factor 1 A-2 Statin-S1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
translation	IBA
translational elongation	ISS
translational elongation	IBA
positive regulation of apoptotic process	IEA
positive regulation of lipid kinase activity	IDA	17088255

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

primary metabolic process [inference]

protein metabolic process [inference]

translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

protein metabolic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

positive regulation of lipid metabolic process [inference]

positive regulation of lipid kinase activity

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of lipid kinase activity [inference]

positive regulation of lipid kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid kinase activity

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

positive regulation of lipid metabolic process [inference]

positive regulation of lipid kinase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of lipid kinase activity [inference]

positive regulation of lipid kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

regulation of lipid kinase activity [inference]

positive regulation of lipid kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of lipid kinase activity

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GO Term	Evidence Code	PMID
nucleus	IDA	12426392
cytoplasm	IDA	12426392
endoplasmic reticulum membrane	IDA	36697828
eukaryotic translation elongation factor 1 complex	IEA
synapse	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation elongation factor 1 complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of lysosomal membrane

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GO Term	Evidence Code	PMID
translation elongation factor activity	ISS
translation elongation factor activity	IBA
GTPase activity	ISS
GTPase activity	IBA
protein binding	IPI	18448518 19559761 25416956 28514442 31046837 31515488 32296183 32814053 33961781

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding

translation elongation factor activity

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding

translation elongation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

elongation factor 1-alpha

Functional Category

J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GTP binding
nucleotide binding

Displaying **all 7** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Tr-type G domain, conserved site
Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
Translation elongation factor EFTu-like, domain 2
Translation elongation factor EFTu/EF1A, C-terminal
Translation protein, beta-barrel domain superfamily
Translational (tr)-type GTP-binding domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070068	autosomal dominant intellectual developmental disorder 38	Alliance of Genome Resources
DOID:0080463	developmental and epileptic encephalopathy 33	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	1915	SGD:S000006284
Xenopus tropicalis	1917	Xenbase:XB-GENE-975439
Saccharomyces cerevisiae S288C	13627	SGD:S000006284
Mus musculus	13628	Xenbase:XB-GENE-975439	MOUSE32337
Rattus norvegicus	24799		RATNO28633
Rattus norvegicus	170848		RATNO28633
Xenopus tropicalis	175975	Xenbase:XB-GENE-975439
Xenopus tropicalis	181044	Xenbase:XB-GENE-975439
Danio rerio	436644		DANRE24998
Pan troglodytes	458406		PANTR25349

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OrthoDB (Group)

International Collaboration

Acknowledgements