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proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

Summary

Gene Symbol

Psme3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19192

PubChem

19192

Alliance of Genome Resources

MGI:1096366

Annotation

Keyword

Acetylation
Apoptosis
Cell cycle
Cytoplasm
Nucleus
Phosphoprotein
Protease
Proteasome
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P61290	11S regulator complex subunit gamma Activator of multicatalytic protease subunit 3 Ki nuclear autoantigen Proteasome activator 28 subunit gamma
Q4FK54	Activator of multicatalytic protease subunit 3 Proteasome activator 28 subunit gamma

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
apoptotic process	IEA
regulation of proteasomal protein catabolic process	ISO
regulation of proteasomal protein catabolic process	IBA
regulation of proteasomal protein catabolic process	IEA
regulation of G1/S transition of mitotic cell cycle	IBA

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

regulation of cell cycle phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IBA
nucleoplasm	IEA
cytoplasm	IBA
cytosol	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

proteasome activator complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

cytosol

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
p53 binding	ISS
p53 binding	ISO
identical protein binding	ISO
identical protein binding	IEA
endopeptidase activator activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

endopeptidase regulator activity [inference]

endopeptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

proteasome activator

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
endopeptidase activator activity
regulation of G1/S transition of mitotic cell cycle
regulation of proteasomal protein catabolic process

Displaying **all 6** entries
InterPro
Proteasome activator PA28, C-terminal domain superfamily
Proteasome activator PA28, C-terminal domain
Proteasome activator PA28, N-terminal domain superfamily
Proteasome activator PA28, N-terminal domain
Proteasome activator PA28
Proteasome activator superfamily

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10197	Xenbase:XB-GENE-981879	HUMAN33956
Xenopus tropicalis	19192	Xenbase:XB-GENE-981879
Rattus norvegicus	25634		RATNO03089
Danio rerio	30649		DANRE46019
Rattus norvegicus	287716		RATNO03089
Sus scrofa	397625		PIGXX02229
Canis lupus familiaris	480512		CANLF18677
Macaca mulatta	711900		MACMU16151
Pan troglodytes	740582		PANTR13827
Ornithorhynchus anatinus	100093159		ORNAN03165